1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

Mirtazapine (Synonyms: Org3770; 6-Azamianserin)

Cat. No.: HY-B0352 Purity: 99.77%
Handling Instructions

Mirtazapine is a potent tetracyclic antidepressant.

For research use only. We do not sell to patients.

Mirtazapine Chemical Structure

Mirtazapine Chemical Structure

CAS No. : 85650-52-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 207 In-stock
Estimated Time of Arrival: December 31
100 mg USD 188 In-stock
Estimated Time of Arrival: December 31
200 mg USD 319 In-stock
Estimated Time of Arrival: December 31
500 mg USD 569 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Mirtazapine is a potent tetracyclic antidepressant. Target: 5-HT Receptor Mirtazapine, the novel antidepressant, has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors [1].Mirtazapine appears to have a substantial ameliorating effect on hot flushes and perspiration bouts. It is postulated that the 5-HT(2A) blocking properties of mirtazapine is accounted in the symptomatic relief of hot flushes [2]. After 4-24 weeks of treatment, mirtazapine induced downregulation of platelet alpha(2A)-adrenoceptors (up to 34%) and Galphai proteins (up to 28%), and the upregulation of GRK 2 (up to 30%). Treatment with mirtazapine reversed this abnormality and induced downregulation of alpha(2A)-adrenoceptor/Galphai complex [3].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7686 mL 18.8430 mL 37.6861 mL
5 mM 0.7537 mL 3.7686 mL 7.5372 mL
10 mM 0.3769 mL 1.8843 mL 3.7686 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight








Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Cat. No.: HY-B0352