Blonanserin dihydrochloride
Based on 1 publication(s) in Google Scholar
Blonanserin dihydrochloride is a potent and orally active 5-HT2A and dopamine D2 receptor antagonist, with Ki values of 0.812 and 0.142 nM, respectively. Blonanserin dihydrochloride is usually acts as an atypical antipsychotic agent, and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension.
For research use only. We do not sell to patients.
- CAS No.: 132812-45-4
- Formula: C23H32Cl2FN3
- Molecular Weight:440.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Blonanserin dihydrochloride
MoreAll 5-HT Receptor Isoforms
MoreAll Dopamine Receptor Isoforms
MoreAll Adrenergic Receptor Isoforms
MoreAll Sigma Receptor Isoforms
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Biological Activity
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5-HT2A Receptor |
D2 Receptor 0.142 nM (Ki) |
D3 Receptor 0.494 nM (Ki) |
D4 Receptor 150 nM (Ki) |
D1 Receptor 1070 nM (Ki) |
5-HT2A Receptor 0.812 nM (Ki) |
5-HT2C Receptor 26.4 nM (Ki) |
5-HT6 Receptor 11.7 nM (Ki) |
α1-adrenergic receptor 26.7 nM (Ki) |
α2-adrenergic receptor 530 nM (Ki) |
Blonanserin dihydrochloride exerts some blockade of α1-adrenergic receptors (Ki=26.7 nM) and also shows significant affinity for the D3 receptor (Ki=0.494 nM). Blonanserin dihydrochloride possesses low affinity for the sigma receptor (IC50=286 nM), but lacks significant affinity for numerous other sites including the 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice received saline or phencyclidine once a day for 14 consecutive days[2]
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Dosage:1 mg/kg
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Administration:Oral gavage; once a day for 14 days
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Result:Had an effect on the social deficit in mice that received repeated PCP administration.
Chemical Information
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CAS No. 132812-45-4
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Molecular Weight 440.42
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Formula C23H32Cl2FN3
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SMILES
FC1=CC=C(C2=C(CCCCCC3)C3=NC(N4CCN(CC)CC4)=C2)C=C1.Cl.Cl
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Synonyms
AD-5423 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Bardoxolone displays potent activity against triple negative breast cancer by inhibiting the TRIP13/STAT3 circuit. [Abstract]2025 Jun;46(6):1733-1741. PMID: 39939802
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Blonanserin dihydrochloride Related Classifications
HY-13575A Related Classifications
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