1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
    Autophagy
  2. Dopamine Receptor
    5-HT Receptor
    Sodium Channel
    Potassium Channel
    Autophagy
  3. Chlorpromazine hydrochloride

Chlorpromazine hydrochloride 

Cat. No.: HY-B0407A Purity: 99.83%
Handling Instructions

Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.

For research use only. We do not sell to patients.

Chlorpromazine hydrochloride Chemical Structure

Chlorpromazine hydrochloride Chemical Structure

CAS No. : 69-09-0

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Chlorpromazine hydrochloride:

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Description

Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.

IC50 & Target

Ki: 363 nM (dopamine D2 receptor), 8.3 nM (5-HT2A receptor)[4]

In Vitro

Chlorpromazine (3, 10, 20, 40, and 60 μM) decreases the peak currents of hNav1.7 in a concentration-dependent manner, with IC50 of 25.9 μM with a Hill coefficient of 2.3. Chlorpromazine (25 μM) produces strong use-dependent inhibition of the hNav1.7 current. Chlorpromazine blocks the hNav1.7 channel, independent of calmodulin[1]. Chlorpromazine blocks HERG potassium channels with an IC50 value of 21.6 μM and a Hill coefficient of 1.11. Chlorpromazine (1, 10, 100 μM) blocks HERG potassium channels expressed in Xenopus laevis oocytes in a concentration-dependent manner. Chlorpromazine blocks HERG potassium channels in the activated state[5].

In Vivo

Chlorpromazine (2 mg/kg, i.p.)-induced neurobehavioural abnormalities (NAs) are characterized by significant increase in cataleptic behaviour and loared spontaneous activity reaction time in mice[2]. Chlorpromazine (1 or 5 mg/kg, i,p.) prevents ketamine (KET) from increasing average spectral power of delta and gamma-high bands on the 5th and 10th days of treatment in rats[3].

Clinical Trial
Molecular Weight

355.33

Formula

C₁₇H₂₀Cl₂N₂S

CAS No.

69-09-0

SMILES

CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 60 mg/mL (168.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8143 mL 14.0714 mL 28.1429 mL
5 mM 0.5629 mL 2.8143 mL 5.6286 mL
10 mM 0.2814 mL 1.4071 mL 2.8143 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[2]

Adult mice (8-10 weeks old) weighing 18-25 g are divided into five groups of six mice per group. The treatment schedule is as follows: Group 1, control (Normal Saline: NS, 10 mL/kg i.p.); Group 2, chlorpromazine (CPZ, 2 mg/kg i.p.); Group 3, bromocriptine (BMC, 2.5 mg/kg s.c.); Group 4: amlodipine (AML, 1 mg/kg s.c.); Group 5, BMC (2.5 mg/kg s.c.) + AML (1 mg/kg). Animal treated with BMC or AML or their combination also receive chlorpromazine 30 min later (i.p.). Animals are subjected to various tests including metal bar test for catalepsy and spontaneous activity wheel for motor assessment and agility and elevated plus maze, hole-board, Y-maze, open-field tests for locomotory activity, and exploratory behaviour respectively. Animals are euthanized eighteen hours later by cervical dislocation. The brain is dissected, rinsed in buffer (pH 7.6) and homogenized with Teflon and used for assessment of lipid peroxidation, reduced glutathione, superoxide dismutase and catalase.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.83%

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Chlorpromazine hydrochloride
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HY-B0407A
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