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Chlorpromazine hydrochloride

147 Cited Publications
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Based on 147 publication(s) in Google Scholar

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.

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  • Purity: 99.82%
  • CAS No.: 69-09-0
  • Formula: C17H20Cl2N2S
  • Molecular Weight:355.33
  • Storage:

    4°C, sealed storage, away from moisture and light

    * The compound is unstable in solutions, freshly prepared is recommended.

  • Chlorpromazine hydrochloride Chemical Structure
    Chlorpromazine hydrochloride Chemical Structure
  • Experimental Validation Results for Chlorpromazine hydrochloride
  • Experimental Validation Results for Chlorpromazine hydrochloride
  • Experimental Validation Results for Chlorpromazine hydrochloride
  • Experimental Validation Results for Chlorpromazine hydrochloride
  • Experimental Validation Results for Chlorpromazine hydrochloride
CAS No.: 69-09-0
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  • Chlorpromazine hydrochloride Chemical Structure
    Chlorpromazine hydrochloride Chemical Structure
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    Chlorpromazine hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 21;10(1):349. [Abstract]

    Customer Validation
     Analysis of the cellular uptake pathways of OVA PCD. Ethamilamiline (EIPA), genistein (GEN), and chlorpromazine (CPZ) (10 μM for 12 h）were used to inhibit macropinocytosis, caveolin-mediated endocytosis, and clathrin-mediated endocytosis, respectively.

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    Chlorpromazine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Mar;37(9):e2415030. [Abstract]

    Customer Validation
     FCM analysis of F/G/H‐GNC internalization by 4T1 cells pre‐treated with various endocytosis inhibitors (n = 3). EIPA: 5‐(N‐ethyl‐N‐isopropyl)‐amiloride, 50 µM; Dyna: dynasore, 50 µg/mL; Me‐β‐CD: methyl‐β‐cyclodextrin, 2.5 mg/mL; CPZ: Chlorpromazine, 10 µg/mL; Cyto D: Cytochalasin D, 2.5 µg/mL; Noco: Nocodazole, 5 µM.

  • 1/16

    Chlorpromazine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Aug 6;36(8):1806-1822.e11. [Abstract]

    Customer Validation
     To clarify the possible pathways responsible for EV uptake by CAFs, BMDM-derived EVs were labeled with DiO, and m-CAFs were labeled with DiL. Chlorpromazine (50 μM, 1h) was used to block EV uptake by m-CAFs.

  • 1/16

    Chlorpromazine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. [Abstract]

    Customer Validation
     Bone marrow cells cultured in medium containing 10 ng/mL GM-CSF for 3 days were treated with 2 μg PKH67-labeled sEVs with or without Amiloride (10 μM), Chlorpromazine (10 μM), or EIPA (5 μM) for 1 h. The median fluorescence intensity (MFI) of PKH67 was assessed by flow cytometry.

  • 1/16

    Chlorpromazine hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2022 Nov 14;5(1):1248. [Abstract]

    Customer Validation
     Chlorpromazine (CPZ) (10 µM; 30 min) remarkably decreases the cellular internalization of FITC-P-LPK in HCT116 cells. Chlorpromazine can inhibit clathrin-mediated endocytosis. The fluorescence intensity is observed by confocal microscopy and detected using a multi-well plate reader.

  • Chlorpromazine hydrochloride