1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
  4. D4 Receptor Isoform
  5. D4 Receptor Antagonist

D4 Receptor Antagonist

D4 Receptor Antagonists (25):

Cat. No. Product Name Effect Purity
  • HY-A0077
    Perphenazine
    Antagonist 99.72%
    Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively.
  • HY-103414
    Raclopride
    Antagonist 99.72%
    Raclopride is a dopamine D2/D3 receptor antagonist with potential antipsychotic effects.
  • HY-14690
    Ecopipam
    Antagonist
    Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively.
  • HY-14325B
    L-745870 hydrochloride
    Antagonist 99.91%
    L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM.
  • HY-10121
    Asenapine
    Antagonist 99.93%
    Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0).
  • HY-13575
    Blonanserin
    Antagonist 98.73%
    Blonanserin (AD-5423) is a potent and orally active 5-HT2A (Ki=0.812 nM) and dopamine D2 receptor (Ki =0.142 nM) antagonist.
  • HY-B1371A
    Spiperone hydrochloride
    Antagonist 99.10%
    Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist.
  • HY-17410
    Iloperidone
    Antagonist 99.95%
    Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist.
  • HY-103104
    Fananserin
    Antagonist 99.97%
    Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor.
  • HY-14782
    Adoprazine
    Antagonist 98.10%
    Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors.
  • HY-110033
    Ecopipam hydrobromide
    Antagonist ≥99.0%
    Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively.
  • HY-14325
    L-745870
    Antagonist 99.88%
    L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM.
  • HY-13575A
    Blonanserin dihydrochloride
    Antagonist
    Blonanserin dihydrochloride is a potent and orally active 5-HT2A and dopamine D2 receptor antagonist, with Ki values of 0.812 and 0.142 nM, respectively.
  • HY-103407A
    PD 168568 dihydrochloride
    Antagonist
    PD 168568 dihydrochloride is a orally active and potent dopamine receptor D4 (DRD4) antagonist.
  • HY-103404
    PNU-96415E
    Antagonist
    PNU-96415E is a selective D4/5-HT2A antagonist.
  • HY-14325A
    L-745870 trihydrochloride
    Antagonist
    L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM.
  • HY-14327
    FAUC 213
    Antagonist
    FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4.
  • HY-108976
    Raclopride tartrate
    Antagonist
    Raclopride tartrate is a selective dopamine D2/D3 receptor antagonist with potential antipsychotic effects.
  • HY-14689
    Ecopipam hydrochloride
    Antagonist
    Ecopipam (SCH 39166) hydrochloride is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively.
  • HY-10121B
    Asenapine citrate
    Antagonist
    Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0).