1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Adoprazine

Adoprazine (Synonyms: SLV313)

Cat. No.: HY-14782 Purity: 98.10%
Handling Instructions

Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics.

For research use only. We do not sell to patients.

Adoprazine Chemical Structure

Adoprazine Chemical Structure

CAS No. : 222551-17-9

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10 mM * 1 mL in DMSO USD 264 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 408 In-stock
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50 mg USD 1080 In-stock
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Description

Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics[1].

IC50 & Target[1]

5-HT1A Receptor

9 (pEC50)

D2 Receptor

9.3 (pA2)

D3 Receptor

8.9 (pA2)

D4 Receptor

8.0 (pKi)

5-HT7 Receptor

7.2 (pKi)

5-HT1A Receptor

9.1 (pKi)

D2 Receptor

8.4 (pKi)

D3 Receptor

8.4 (pKi)

In Vitro

Adoprazine (SLV313) has high affinity at human recombinant D2, D3, D4, 5-HT2B, and 5-HT1A receptors, with pKis of 8.4, 8.4, 8.0, 7.9 and 9.1, respectively[1]. Adoprazine (SLV313) acts as a high potency dopamine D2 receptor antagonist and an efficacious serotonin 5-HT1A receptor agonist, with Emax value (% effect of 10 μM 5-HT) of 73 and pKB value of 8.5 [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Adoprazine (SLV313) (0.1-10 mg/kg; p.o.; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (275-350 g) [1]
Dosage: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: p.o.; single
Result: Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.
Clinical Trial
Molecular Weight

405.46

Formula

C₂₄H₂₄FN₃O₂

CAS No.

222551-17-9

SMILES

FC1=CC=C(C2=CN=CC(CN3CCN(C4=C5OCCOC5=CC=C4)CC3)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4663 mL 12.3317 mL 24.6633 mL
5 mM 0.4933 mL 2.4663 mL 4.9327 mL
10 mM 0.2466 mL 1.2332 mL 2.4663 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (7.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 30 mg/mL (73.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AdoprazineSLV313SLV 313SLV-3135-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorserotonindopamineantipsychoticInhibitorinhibitorinhibit

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Adoprazine
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