2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. 5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor
  4. Asenapine

Asenapine  (Synonyms: Org 5222)

Cat. No.: HY-10121 Purity: 99.93%
COA Handling Instructions

Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.

For research use only. We do not sell to patients.

Asenapine Chemical Structure

Asenapine Chemical Structure

CAS No. : 65576-45-6

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Solution
10 mM * 1 mL in DMSO USD 158 In-stock
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ready for reconstitution
 USD 158 In-stock
Solid
10 mg USD 144 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Asenapine:

Asenapine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Asenapine

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

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  • References

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Description

Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder[1][2].

IC50 & Target[5]

5-HT1A Receptor

8.6 (pKi)

5-HT1B Receptor

8.4 (pKi)

5-HT2A Receptor

10.2 (pKi)

5-HT2B Receptor

9.8 (pKi)

5-HT2C Receptor

10.5 (pKi)

5-HT5 Receptor

8.8 (pKi)

5-HT6 Receptor

9.6 (pKi)

5-HT7 Receptor

9.9 (pKi)

Alpha-2A adrenergic receptor

8.9 (pKi)

α1-adrenergic receptor

8.9 (pKi)

Alpha-2B adrenergic receptor

9.5 (pKi)

Alpha-2C adrenergic receptor

8.9 (pKi)

D1 Receptor

8.9 (pKi)

D2 Receptor

8.9 (pKi)

D3 Receptor

9.4 (pKi)

D4 Receptor

9.0 (pKi)

H1 Receptor

9.0 (pKi)

H2 Receptor

8.2 (pKi)

In Vivo

Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (200-250 g)[2]
Dosage: 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg
Administration: Subcutaneous injection
Result: Produced suppression of CAR in a dose-dependent manner.
Clinical Trial
Molecular Weight

285.77

Appearance

Solid

Formula

C17H16ClNO
CAS No.
SMILES

ClC1=CC=C2OC3=CC=CC=C3[C@@](C4)([H])[C@](CN4C)([H])C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (699.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4993 mL 17.4966 mL 34.9932 mL
5 mM 0.6999 mL 3.4993 mL 6.9986 mL
10 mM 0.3499 mL 1.7497 mL 3.4993 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (8.75 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.75 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Asenapine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Asenapine65576-45-6Org 5222Org5222Org-52225-HT ReceptorAdrenergic ReceptorDopamine ReceptorHistamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorpsychopharmacologicpsychopharmacologicaldopamineserotoninnoradrenalinenorepinephrinehistaminereceptorsubtypesschizophreniabipolar disorder，antidepressantInhibitorinhibitorinhibit

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