2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. 5-HT Receptor Dopamine Receptor Adrenergic Receptor Histamine Receptor
  4. Asenapine citrate

Asenapine citrate  (Synonyms: Org 5222 citrate)

Cat. No.: HY-10121B
Handling Instructions

Molarity Calculator

Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder.

For research use only. We do not sell to patients.

Asenapine citrate Chemical Structure

Asenapine citrate Chemical Structure

CAS No. : 1411867-74-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Asenapine citrate:

Other Forms of Asenapine citrate:

Asenapine citrate Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms
α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].

IC50 & Target

5-HT1B Receptor

8.4 (pKi)

5-HT1A Receptor

8.6 (pKi)

5-HT5 Receptor

8.8 (pKi)

5-HT6 Receptor

9.6 (pKi)

5-HT2B Receptor

9.8 (pKi)

5-HT7 Receptor

9.9 (pKi)

5-HT2A Receptor

10.2 (pKi)

5-HT2C Receptor

10.5 (pKi)

α1-adrenergic receptor

8.9 (pKi)

Alpha-2A adrenergic receptor

8.9 (pKi)

Alpha-2C adrenergic receptor

8.9 (pKi)

Alpha-2B adrenergic receptor

9.5 (pKi)

D1 Receptor

8.9 (pKi)

D2 Receptor

8.9 (pKi)

D4 Receptor

9.0 (pKi)

D3 Receptor

9.4 (pKi)

H2 Receptor

8.2 (pKi)

H1 Receptor

9.0 (pKi)

In Vivo

Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

477.89

Formula

C23H24ClNO8
CAS No.
SMILES

ClC1=CC=C2OC3=CC=CC=C3[C@@](C4)([H])[C@](CN4C)([H])C2=C1.O=C(CC(C(O)=O)(O)CC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Asenapine citrate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asenapine1411867-74-7Org 5222Org5222Org-52225-HT ReceptorDopamine ReceptorAdrenergic ReceptorHistamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorpsychopharmacologicpsychopharmacologicaldopamineserotoninnoradrenalinenorepinephrinehistamineschizophreniabipolar disorderantidepressantInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Asenapine citrate
Cat. No.:
HY-10121B
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.