Asenapine citrate
Based on 2 publication(s) in Google Scholar
Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder.
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- No. CAS: 1411867-74-7
- Fòrmula: C23H24ClNO8
- Peso molecular:477.89
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Asenapine citrate
MoreVer todos los productos específicos de isoformas 5-HT Receptor
MoreVer todos los productos específicos de isoformas Dopamine Receptor
MoreVer todos los productos específicos de isoformas Adrenergic Receptor
MoreVer todos los productos específicos de isoformas Histamine Receptor
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Actividad biológica
Descripciòn
IC50 & Target
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Alpha-2C adrenergic receptor 8.9 (pKi) |
Alpha-2B adrenergic receptor 9.5 (pKi) |
Alpha-2A adrenergic receptor 8.9 (pKi) |
α1-adrenergic receptor 8.9 (pKi) |
5-HT2C Receptor 10.5 (pKi) |
5-HT2A Receptor 10.2 (pKi) |
5-HT2B Receptor 9.8 (pKi) |
5-HT5 Receptor 8.8 (pKi) |
5-HT6 Receptor 9.6 (pKi) |
5-HT7 Receptor 9.9 (pKi) |
5-HT1A Receptor 8.6 (pKi) |
5-HT1B Receptor 8.4 (pKi) |
D2 Receptor 8.9 (pKi) |
D1 Receptor 8.9 (pKi) |
H2 Receptor 8.2 (pKi) |
D4 Receptor 9 (pKi) |
D3 Receptor 9.4 (pKi) |
H1 Receptor 9 (pKi) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1411867-74-7
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Peso molecular 477.89
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Fòrmula C23H24ClNO8
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SMILES
ClC1=CC=C2OC3=CC=CC=C3[C@@](C4)([H])[C@](CN4C)([H])C2=C1.O=C(CC(C(O)=O)(O)CC(O)=O)O
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Synonyms
Org 5222 citrate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Biomed Pharmacother
Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies. [Abstract]2025 Jan:182:117756. PMID: 39693907
Pureza y Documentación
Referencias
[1]. M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [Content Brief]
[2]. Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asenapine citrate Related Classifications
HY-10121B Related Classifications
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Keywords
- Asenapine
- 1411867-74-7
- Org 5222
- Org5222
- Org-5222
- 5-HT Receptor
- Dopamine Receptor
- Adrenergic Receptor
- Histamine Receptor
- Serotonin Receptor
- 5-hydroxytryptamine Receptor
- Beta Receptor
- psychopharmacologic
- psychopharmacological
- dopamine
- serotonin
- noradrenaline
- norepinephrine
- histamine
- schizophrenia
- bipolar disorder
- antidepressant
- Inhibitor
- inhibitor
- inhibit