Asenapine-13C,d3
Asenapine-13C,d3 is 13C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.
For research use only. We do not sell to patients.
- CAS No.: 2747915-30-4
- Formula: C2013CH17D3ClNO5
- Molecular Weight:405.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
MoreAll Dopamine Receptor Isoforms
MoreAll 5-HT Receptor Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2747915-30-4
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Unlabeled Cas 65576-45-6
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Molecular Weight 405.85
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Formula C2013CH17D3ClNO5
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SMILES
ClC1=CC(C2C(CN(C2)[13C]([2H])([2H])[2H])C3=C4C=CC=C3)=C(O4)C=C1.O=C(O)/C=C\C(O)=O
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Synonyms
Org 5222-13C,d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [Content Brief]
[3]. Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asenapine-13C,d3 Related Classifications
Cat. No.: HY-10121S2
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- Asenapine-13C,d3
- 2747915-30-4
- Org 5222-13C,d3
- Adrenergic Receptor
- Dopamine Receptor
- 5-HT Receptor
- Histamine Receptor
- Isotope-Labeled Compounds
- psychopharmacologic
- psychopharmacological
- dopamine
- serotonin
- noradrenaline
- norepinephrine
- histamine
- receptor
- subtypes
- schizophrenia
- bipolar disorder
- antidepressant
- Inhibitor
- inhibitor
- inhibit