1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Dopamine D4 receptor antagonist-1

Dopamine D4 receptor antagonist-1 

Cat. No.: HY-147398
Handling Instructions

Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia.

For research use only. We do not sell to patients.

Dopamine D4 receptor antagonist-1 Chemical Structure

Dopamine D4 receptor antagonist-1 Chemical Structure

CAS No. : 444724-92-9

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Description

Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1].

In Vivo

Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT)[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection, single.
Result: Increased DOPA accumulation in the hippocampus with no effect observed in the striatum.
Molecular Weight

326.82

Formula

C18H19ClN4

CAS No.
SMILES

ClC1=CC(N2CCN(CC2)CC3=NC4=C(N3)C=CC=C4)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Dopamine D4 receptor antagonist-1
Cat. No.:
HY-147398
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