2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Dopamine D4 receptor antagonist-1

Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia.

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Dopamine D4 receptor antagonist-1 Chemical Structure

Dopamine D4 receptor antagonist-1 Chemical Structure

CAS No. : 444724-92-9

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Dopamine D4 receptor antagonist-1 Related Antibodies

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Description

Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1].

IC50 & Target

hD4.2 Receptor

9.0 nM (Ki)

In Vivo

Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT)[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection, single.
Result: Increased DOPA accumulation in the hippocampus with no effect observed in the striatum.
Molecular Weight

326.82

Formula

C18H19ClN4
CAS No.
SMILES

ClC1=CC(N2CCN(CC2)CC3=NC4=C(N3)C=CC=C4)=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dopamine D4 receptor antagonist-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dopamine D4 receptor antagonist-1444724-92-9Dopamine ReceptorDopamine D4 receptorDAschizophreniaInhibitorinhibitorinhibit

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