1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Sonepiprazole

Sonepiprazole (Synonyms: PNU-101387G; U-101387G)

Cat. No.: HY-14328
Handling Instructions

Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively.

For research use only. We do not sell to patients.

Sonepiprazole Chemical Structure

Sonepiprazole Chemical Structure

CAS No. : 170858-33-0

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Description

Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively[1].

IC50 & Target[1]

rD4 Receptor

3.6 nM (Ki)

hD4 Receptor

10.1 nM (Ki)

rD2 Receptor

5147 nM (Ki)

Histamine H1 Receptor

7430 nM (Ki)

In Vitro

Sonepiprazole exhibits highly specific binding to the D4 dopamine receptor with more than 100-fold selectivity for the D4 receptor over other receptors, including dopamine, serotonin, and adrenergic receptors[1].

Molecular Weight

401.52

Formula

C₂₁H₂₇N₃O₃S

CAS No.

170858-33-0

SMILES

O=S(C1=CC=C(N2CCN(CC[[email protected]]3C4=CC=CC=C4CCO3)CC2)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SonepiprazolePNU-101387GU-101387GDopamine ReceptorInhibitorinhibitorinhibit

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