244276-65-1
Chemical Structure
NRA-0562
- CAS No.: 244276-65-1
- Formula:C25H24F2N4OS
- Molecular Weight:466.55
InChIKey: KGCLWPBGLDFQHP-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C2=CC=C(C=C2)F)=C(CCN3CCC(CC3)C4=CNC5=C4C=CC(F)=C5)S1)N
Biological Activity: NRA‑0562 is a dopamine antagonist with high affinities for dopamine D1/D2/D3/D4, 5‑HT2A and α1‑adrenoceptors. NRA-0562 dose‑dependently reverses induced suppression of firing activity in rat A9 and A10 midbrain dopamine neurons, with preferential potency at A10 neurons (ED50 = 0.3 mg/kg). NRA-0562 elevates Fos-like immunoreactivity in rat nucleus accumbens and dorsolateral striatum. NRA-0562 can be used for preclinical research on schizophrenia[1].[1].
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NRA-0562 | NRA‑0562 is a dopamine antagonist with high affinities for dopamine D1/D2/D3/D4, 5‑HT2A and α1‑adrenoceptors. NRA-0562 dose‑dependently reverses induced suppression of firing activity in rat A9 and A10 midbrain dopamine neurons, with preferential potency at A10 neurons (ED50 = 0.3 mg/kg). NRA-0562 elevates Fos-like immunoreactivity in rat nucleus accumbens and dorsolateral striatum. NRA-0562 can be used for preclinical research on schizophrenia.. | |||||||||||||||||||||
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Keywords
