1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter
  3. (+)-Tetrabenazine

(+)-Tetrabenazine (Synonyms: (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine)

Cat. No.: HY-B0590B Purity: 99.81% ee.: 99.76%
Handling Instructions

(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

For research use only. We do not sell to patients.

(+)-Tetrabenazine Chemical Structure

(+)-Tetrabenazine Chemical Structure

CAS No. : 1026016-83-0

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10 mM * 1 mL in DMSO USD 66 In-stock
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5 mg USD 60 In-stock
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10 mg USD 84 In-stock
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50 mg USD 180 In-stock
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100 mg USD 288 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (+)-Tetrabenazine:

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Description

(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2]

Molecular Weight

317.42

Formula

C₁₉H₂₇NO₃

CAS No.

1026016-83-0

SMILES

COC1=C(OC)C=C(CCN(C[[email protected]]2CC(C)C)[[email protected]]3([H])CC2=O)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (315.04 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1504 mL 15.7520 mL 31.5040 mL
5 mM 0.6301 mL 3.1504 mL 6.3008 mL
10 mM 0.3150 mL 1.5752 mL 3.1504 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.81% ee.: 99.76%

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(+)-Tetrabenazine
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