1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter
  3. Tetrabenazine

Tetrabenazine (Synonyms: Ro 1-9569)

Cat. No.: HY-B0590 Purity: 99.10%
Handling Instructions

Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.

For research use only. We do not sell to patients.

Tetrabenazine Chemical Structure

Tetrabenazine Chemical Structure

CAS No. : 58-46-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 96 In-stock
Estimated Time of Arrival: December 31
100 mg USD 120 In-stock
Estimated Time of Arrival: December 31
200 mg USD 156 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Tetrabenazine:

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Description

Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. Target: Others tetrabenazine (TBZ), a monoamine-depleting and a dopamine-receptor-blocking drug. TBZ is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. In contrast to typical neuroleptics, TBZ has not been demonstrated to cause tardive dyskinesia [1, 2]. Twenty patients with tardive dyskinesia (mean duration = 43.7 months) were videotaped before and after tetrabenazine treatment. One patient did not tolerate tetrabenazine owing to sedation. The remaining 19 were rated after a mean of 20.3 weeks at a mean tetrabenazine dose of 57.9 mg/day. There were significant improvements in mean scores on both the patient AIMS self-rating and the AIMS motor subset evaluated by the blind videotape raters. All 19 patients continued to take tetrabenazine after the study [3].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 3.2 mg/mL (10.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1504 mL 15.7520 mL 31.5040 mL
5 mM 0.6301 mL 3.1504 mL 6.3008 mL
10 mM 0.3150 mL 1.5752 mL 3.1504 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

317.42

Formula

C₁₉H₂₇NO₃

CAS No.

58-46-8

SMILES

O=C1[[email protected]@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[[email protected]]2([H])C1.[relative stereochemistry]

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.10%

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Product Name:
Tetrabenazine
Cat. No.:
HY-B0590
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Tetrabenazine

Cat. No.: HY-B0590