1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter
  3. Tetrabenazine

Tetrabenazine  (Synonyms: Ro 1-9569)

Cat. No.: HY-B0590 Purity: ≥99.0%
COA Handling Instructions

Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.

For research use only. We do not sell to patients.

Tetrabenazine Chemical Structure

Tetrabenazine Chemical Structure

CAS No. : 58-46-8

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10 mM * 1 mL in DMSO USD 99 In-stock
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Description

Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease[1][2][3].

In Vivo

Tetrabenazine (subcutaneous injection, 1-10 mg/kg, once) can reduce the aggressive behavior in a dose-dependent manner and the levels of neurotransmitter molecules NE, DA and 5-HT in adult male mice[1].
Tetrabenazine (intraperitoneal injection, 0-2 mg/kg, once) has selective effects on movement which can significantly attenuate morphine-induced hypermobility but oral tremors and stereotyped behaviors in male ICR mice[2].
Tetrabenazine (intraperitoneal injection, 0.25-2 mg/kg, once a week) increases tremulous jaw movement (TJM) in a dose-dependent manner in adult male Sprague-Dawley rat[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male MAO A KO or wide type mice aged 1-2 months[1]
Dosage: 1-10 mg/kg
Administration: Subcutaneous injection; once
Result: Completely eliminated the aggressive behavior at a concentration of 5 mg/kg and significantly reduced their NE, DA and 5-HT levels.
Animal Model: Male ICR mice (10 weeks old)[2]
Dosage: 0-2 mg/kg
Administration: Intraperitoneal injection; once
Result: Attenuated the subsequent morphine-induced hypermobility after pretreatment with tetrabenazine. Reduced METH-induced increases in locomotion at 1 mg/kg.
Animal Model: Adult male Sprague-Dawley rat weighed 350-450 g[3]
Dosage: 0.25-2 mg/kg
Administration: Intraperitoneal injection; once a week
Result: Induced tremulous jaw movement (TJM) significantly at the concentration of 2 mg/kg and more motor impairments with higher doses such as 3-4 mg/kg.
Clinical Trial
Molecular Weight

317.42

Formula

C19H27NO3

CAS No.
SMILES

O=C1[[email protected]@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[[email protected]]2([H])C1.[relative stereochemistry]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (105.00 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1504 mL 15.7520 mL 31.5040 mL
5 mM 0.6301 mL 3.1504 mL 6.3008 mL
10 mM 0.3150 mL 1.5752 mL 3.1504 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.88 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.88 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tetrabenazine
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