Tetrabenazine mesylate (Synonyms: Ro 1-9569 mesylate)

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Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the K_d value of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.

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Tetrabenazine mesylate Chemical Structure

CAS No. : 804-53-5

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Description

In Vivo

Tetrabenazine mesylate (subcutaneous injection, 1-10 mg/kg, once) can reduce the aggressive behavior in a dose-dependent manner and the levels of neurotransmitter molecules NE, DA and 5-HT in adult male mice^[1].
Tetrabenazine mesylate (intraperitoneal injection, 0-2 mg/kg, once) has selective effects on movement which can significantly attenuate morphine-induced hypermobility but oral tremors and stereotyped behaviors in male ICR mice^[2].
Tetrabenazine mesylate (intraperitoneal injection, 0.25-2 mg/kg, once a week) increases tremulous jaw movement (TJM) in a dose-dependent manner in adult male Sprague-Dawley rat^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male MAO A KO or wide type mice aged 1-2 months^[1]
Dosage:	1-10 mg/kg
Administration:	Subcutaneous injection; once
Result:	Completely eliminated the aggressive behavior at a concentration of 5 mg/kg and significantly reduced their NE, DA and 5-HT levels.

Animal Model:	Male ICR mice (10 weeks old)^[2]
Dosage:	0-2 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Attenuated the subsequent morphine-induced hypermobility after pretreatment with tetrabenazine. Reduced METH-induced increases in locomotion at 1 mg/kg.

Animal Model:	Adult male Sprague-Dawley rat weighed 350-450 g^[3]
Dosage:	0.25-2 mg/kg
Administration:	Intraperitoneal injection; once a week
Result:	Induced tremulous jaw movement (TJM) significantly at the concentration of 2 mg/kg and more motor impairments with higher doses such as 3-4 mg/kg.

Clinical Trial

Molecular Weight

413.53

Formula

C₂₀H₃₁NO₆S

CAS No.

804-53-5

SMILES

CS(=O)(O)=O.O=C1[C@@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[C@]2([H])C1.[relative stereochemistry]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. J C Shih, et al. Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A. Brain Res. 1999 Jul 24;835(2):104-12. [Content Brief]

[2]. Nobue Kitanaka, et al. Tetrabenazine, a vesicular monoamine transporter-2 inhibitor, attenuates morphine-induced hyperlocomotion in mice through alteration of dopamine and 5-hydroxytryptamine turnover in the cerebral cortex. Pharmacol Biochem Behav. 2018 [Content Brief]

[3]. S J Podurgiel, et al. The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor. Neuroscience. 2013 Oct 10;250:507-19. doi: 10.1016/j.neu [Content Brief]

Tetrabenazine mesylate Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrabenazine804-53-5Ro 1-9569Monoamine TransporterVMAT2 inhibitorHuntington’s diseaseAggressionTremorInhibitorinhibitorinhibit

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