Referencia número: HY-13757

Tamoxifen Citrate

(Synonyms: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate)

259 Cited Publications

Revisión del cliente

Based on 259 publication(s) in Google Scholar

Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.88%
No. CAS: 54965-24-1
Fòrmula: C₃₂H₃₇NO₈
Peso molecular:563.64

Almacenamiento:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Tamoxifen Citrate Chemical Structure

No. CAS: 54965-24-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Induced Disease Models
Chemical Information
Publications (259)
Solvente y solubilidad
- In Vitro
Protocolo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]^[4]

Estrogen receptor

HSP90

Ver todos los productos específicos de isoformas Estrogen Receptor/ERR :

Ver todos los productos específicos de isoformas HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	7 μg/mL Compound: TAM	Effective dose for reduction in cell growth of human skin cancer A431 cell line Effective dose for reduction in cell growth of human skin cancer A431 cell line	[PMID: 15509181]
DU-145	IC₅₀	11.2 μM Compound: Tam citrate	Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 30772606]
DU-145	IC₅₀	15.25 μM Compound: Tamoxifen citrate	Cytotoxicity against human DU145 cells after 18 hrs by MTT assay Cytotoxicity against human DU145 cells after 18 hrs by MTT assay	[PMID: 19932024]
HEK293	IC₅₀	27.3 μM Compound: Tam citrate	Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 30772606]
HEK293	IC₅₀	30 μM Compound: Tamoxifen citrate	Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 29352645]
Ishikawa	IC₅₀	12.5 μM Compound: Tamoxifen citrate	Cytotoxicity against human Ishikawa cells after 18 hrs by MTT assay Cytotoxicity against human Ishikawa cells after 18 hrs by MTT assay	[PMID: 19932024]
KB	ED₅₀	9 μg/mL Compound: TAM	Dose required for reduction in cell growth of human nasopharyngeal carcinoma KB cell line Dose required for reduction in cell growth of human nasopharyngeal carcinoma KB cell line	[PMID: 15509181]
KB	ED₅₀	9 μg/mL Compound: TAM	Dose required for reduction in cell growth of vincristine-resistant human nasopharyngeal carcinoma KB cell line Dose required for reduction in cell growth of vincristine-resistant human nasopharyngeal carcinoma KB cell line	[PMID: 15509181]
LNCaP	ED₅₀	6 μg/mL Compound: TAM	Dose required for reduction in cell growth of human AR-dependent prostate cancer LN-CaP cell line Dose required for reduction in cell growth of human AR-dependent prostate cancer LN-CaP cell line	[PMID: 15509181]
MCF7	ED₅₀	5 μg/mL Compound: TAM	Dose required for reduction in cell growth of estrogen positive human breast cancer MCF-7 cell line (ER+) Dose required for reduction in cell growth of estrogen positive human breast cancer MCF-7 cell line (ER+)	[PMID: 15509181]
MCF7	IC₅₀	0.796 μM Compound: Tamoxifen citrate	Inhibition of 17-beta estradiol-induced cell proliferation in human MCF7 cells incubated for 6 days by acid red-52 staining based assay Inhibition of 17-beta estradiol-induced cell proliferation in human MCF7 cells incubated for 6 days by acid red-52 staining based assay	[PMID: 28882502]
MCF7	IC₅₀	10.2 μM Compound: Tamoxifen citrate	Cytotoxicity against human MCF7 cells after 18 hrs by MTT assay Cytotoxicity against human MCF7 cells after 18 hrs by MTT assay	[PMID: 19932024]
MCF7	IC₅₀	13.7 μM Compound: Tamoxifen citrate	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 29352645]
MCF7	IC₅₀	6.2 μM Compound: Tam citrate	Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 30772606]
MCF7	IC₅₀	9.53 μM Compound: Tamoxifen citrate	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay	[PMID: 32947093]
MDA-MB-231	ED₅₀	8 μg/mL Compound: TAM	Dose required for reduction in cell growth of estrogen negative human breast cancer MDA-MB-231 cell line (ER-) Dose required for reduction in cell growth of estrogen negative human breast cancer MDA-MB-231 cell line (ER-)	[PMID: 15509181]
MDA-MB-231	IC₅₀	10.71 μM Compound: Tamoxifen citrate	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay	[PMID: 32947093]
MDA-MB-231	IC₅₀	12.3 μM Compound: Tamoxifen citrate	Cytotoxicity against human MDA-MB-231 cells after 18 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 18 hrs by MTT assay	[PMID: 19932024]
MDA-MB-231	IC₅₀	12.8 μM Compound: Tam citrate	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 30772606]
MDA-MB-231	IC₅₀	17.9 μM Compound: Tamoxifen citrate	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 29352645]
PC-3	ED₅₀	10 μg/mL Compound: TAM	Dose required for reduction in cell growth of human prostate cancer PC-3 cell line Dose required for reduction in cell growth of human prostate cancer PC-3 cell line	[PMID: 15509181]
PC-3	IC₅₀	11.7 μM Compound: Tam citrate	Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 30772606]
SK-BR-3	ED₅₀	5 μg/mL Compound: TAM	Dose required for reduction in cell growth of estrogen negative human breast cancer SK-BR-3 cell line(ER-) Dose required for reduction in cell growth of estrogen negative human breast cancer SK-BR-3 cell line(ER-)	[PMID: 15509181]
SW-620	ED₅₀	4 μg/mL Compound: TAM	Dose required for reduction in cell growth of human colon cancer SW620 cell line Dose required for reduction in cell growth of human colon cancer SW620 cell line	[PMID: 15509181]
Vero C1008	CC₅₀	37.96 μM Compound: Tamoxifen Citrate	CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells	10.1101/2020.03.25.008482
Vero C1008	CC₅₀	37.96 μM Compound: Tamoxifen Citrate	CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells	10.1101/2020.03.25.008482
Vero C1008	IC₅₀	34.12 μM Compound: Tamoxifen Citrate	IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells	10.1101/2020.03.25.008482
Vero C1008	IC₅₀	8.98 μM Compound: Tamoxifen Citrate	IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells	10.1101/2020.03.25.008482
ZR-75-1	ED₅₀	5 μg/mL Compound: TAM	Dose required for reduction in cell growth of estrogen positive human breast cancer ZR-75-1 cell line (ER+) Dose required for reduction in cell growth of estrogen positive human breast cancer ZR-75-1 cell line (ER+)	[PMID: 15509181]

In Vitro

Tamoxifen Citrate (ICI 46474) shows strong inhibition of MCF-7 cells (EC₅₀=1.41 μM) and to a lesser extent the T47D cells (EC₅₀=2.5 μM) but does not affect the MDA-MB-231 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Induced Disease Models

Note: Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

1. Induction of gene knockout^[7]^[8]

Background

Gene knockout model induced by Tamoxifen Citrate uses Cre-Loxp mice. The Cre recombinase in these mice is driven by a tissue/cell-specific promoter, and the target gene is flanked by Loxp sites. The Cre recombinase is fused with the ligand-binding domain of the estrogen receptor to construct a Cre-ER fusion protein, and the recombination activity of Cre is induced by Tamoxifen Citrate. In the absence of Tamoxifen Citrate, the Cre-ER fusion protein binds to HSP90 and remains in the cytoplasm. After Tamoxifen Citrate induction, the metabolite of Tamoxifen Citrate, 4-OHT, binds to the Cre-ER protein, activates the Cre recombinase, and allows it to enter the nucleus. There, it recognizes the Loxp sites and mediates the knockout of the gene between two (in the same orientation) Loxp sites. (To avoid interference from endogenous estrogens, the ligand-binding domain of the estrogen receptor is modified, transforming Cre-ER into MerCreMer, Cre-ERT, or Cre-ERT2).

Specific Modeling Methods

Cx3cr1^CreERT/+: Pdgfb^fl/fl mice (Conditional knockout of Pdgfb in microglia)
Administration: 75 mg/kg • i.p. • once daily for 5 consecutive days

Note

(1) Dissolution: Tamoxifen is poorly soluble in water and is generally dissolved in Corn oil (HY-Y1888). It can be heated at 37°C or sonicated to assist dissolution, ensuring complete dissolution. Tamoxifen should be prepared in the dark and is recommended to be used freshly prepared. Corn oil is relatively viscous. When aspirating the solution, the needle can be left unplugged. After aspirating the solution, attach the needle and expel the air bubbles.
(2) Administration methods: Common methods include intraperitoneal injection, and it can also be administered by oral gavage or subcutaneous injection. When performing multiple intraperitoneal injections, the injection sites should be alternated.
(3) Dosage: The dosage is 50-120 mg/kg, with 3-5 intraperitoneal injections, usually for 5 consecutive days. The dosage for pregnant mice and aged mice (over 6 months old) should be appropriately reduced. Tamoxifen can affect fetal development and parturition. For pregnant mice, the induction time should preferably be selected in the late pregnancy stage, and progesterone should be injected simultaneously to reduce the probability of miscarriage.
(4) Mice: Mice at 4-6 weeks old may be more sensitive (it is more effective in young mice than in old mice).
(5) Potential toxicity: Prolonged high-level Cre activity can cause potential toxicity. In addition, if an important functional gene is knocked out or using Homozygous Mice, it may also lead to the death of mice. Therefore, close observation should be carried out within one or two weeks after induction. If the mice show abnormalities, the causes need to be analyzed in a timely manner and the experimental plan should be adjusted.
(6) Control: Control group mice should be injected with an equal amount of the corn oil solution of Tamoxifen (using Tamoxifen in a genetic background without Cre recombinase) to rule out the influence of Tamoxifen itself.
(7) Detection window: The time window between Tamoxifen administration and the start of the experiment should be large enough, at least 7 days, to ensure that the Cre recombinase enters the nucleus and functions.
(8) Separate caging: Animals treated with Tamoxifen should be caged separately from untreated animals to avoid cross - contamination caused by behaviors such as animals licking the oily Tamoxifen suspension, grooming their fur, or coprophagy.

Modeling Indicators

Verify the reduced expression/knockout of the target gene at the RNA or protein level through molecular biology and genetic methods (such as Western blot, PCR, and sequencing, etc.).

Correlated Product(s): 4-Hydroxytamoxifen (HY-16950)

2. Induction of liver injury^[9]^[10]

Background

Tamoxifen Citrate reduces the hexose monophosphate shunt, thereby increasing the incidence of oxidative stress in rat hepatocytes, leading to liver injury.

Specific Modeling Methods

Albino rat • female
Administration: 45 mg/kg • i.p. • once daily for 7 days

Note

(1) The rats were kept in a standard laboratory environment, which was a 12-hour light/12-hour dark cycle with the temperature maintained at 25 ± 2°C. They had free access to food and water.
(2) At the end of the experiment, the animals were euthanized by cervical dislocation under mild ether anesthesia. The blood samples were collected in heparinized centrifuge tubes and centrifuged to obtain serum. The abdomen was opened, and the liver was immediately dissected and removed. It was washed with ice-cold isotonic saline and blotted between two filter papers. The liver was wrapped in aluminum foil and stored at -80°C. A 10% (w/v) liver homogenate was prepared in ice-cold 0.1 M potassium phosphate buffer (pH 7.5) using an ultrasonicator.

Modeling Indicators

Molecular Changes: The activities of antioxidant enzymes, including glutathione S-transferase, glutathione peroxidase, and catalase, were significantly ↓, while the content of reduced glutathione also showed a ↓ trend. Concurrently, the levels of thiobarbituric acid reactive substances (TBARS) and liver transaminases, including serum glutamic-pyruvic transaminase (sGPT) and serum glutamic-oxaloacetic transaminase (sGOT), were significantly ↑.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 54965-24-1
Appearance Solid
Peso molecular 563.64
Fòrmula C₃₂H₃₇NO₈
Color White to off-white
SMILES

CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O
Synonyms

ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Publications (259)

All Flow CytometryIn Vivo Efficacy StudyHistological Imaging/StainingIHCWBCell Imaging/Staining

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Journal Impact Factor

Signal Transduct Target Ther

Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. [Abstract]

2023 Feb 3;8(1):51. PMID: 36732502
Cancer Cell

Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity. [Abstract]

2026 Feb 9;44(2):424-442.e14. PMID: 41544628
Cancer Cell

In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy. [Abstract]

2024 Nov 11;42(11):1955-1969.e7. PMID: 39532065

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7. [Abstract]

Peripheral blood chimerism (%Cd45.2) in mice engrafted with WT (Cd45.1) and Flt3^Frt-ITD (Cd45.2) cells following treatment with Tamoxifen (4 mg/mouse; p.o.) (red) or control (black).

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7. [Abstract]

Flt3^Frt-ITD (red), Dnmt3a^Lox-R878H-Flt3^Frt-ITD (orange), and Npm1^Frt-c-Flt3^Frt-ITD (green) bone marrow was transplanted into lethally irradiated hosts. Kaplan-Meier survival plot following TAM (4 mg/mouse; p.o.).

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7. [Abstract]

Bone marrow H&E from either control mice or after 7 days of TAM (4 mg/mouse; p.o.).

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7. [Abstract]

Immunohistochemical staining on bone marrow for Ki67 (left) and phopsho-ERK1/2 (right) for untreated (top) and 7-day TAM (4 mg/mouse; p.o.) treated (bottom) Npm1^Lox-C-Flt3^GL-ITD mice.
Science

Zonated mechanosensing by PIEZO1 controls liver regeneration. [Abstract]

2026 Jul 2;393(6806):eaef0825. PMID: 42391361
Science

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors. [Abstract]

2026 Mar 19;391(6791):eadu7686. PMID: 41855345
Cell

Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration. [Abstract]

2025 Sep 18;188(19):5194-5211.e16. PMID: 40695281
Cell

Red blood cells undergo lytic programmed cell death involving NLRP3. [Abstract]

2025 May 29;188(11):3013-3029.e19. PMID: 40252640
Cell

Multi-layered computational gene networks by engineered tristate logics. [Abstract]

2024 Sep 5;187(18):5064-5080.e14. PMID: 39089254
Cell

Large-scale multiplexed mosaic CRISPR perturbation in the whole organism. [Abstract]

2022 Aug 4;185(16):3008-3024.e16. PMID: 35870449
Cell Res

Neurovascular coupling in the basolateral amygdala modulates negative emotions. [Abstract]

2026 May 27. PMID: 42191977
Cell Res

Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. [Abstract]

2025 Feb;35(2):97-116. PMID: 39757301
Immunity

Renal macrophages monitor and remove particles from urine to prevent tubule obstruction. [Abstract]

2024 Jan 9;57(1):106-123.e7. PMID: 38159573
Immunity

Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension. [Abstract]

2022 Aug 9;55(8):1466-1482.e9. PMID: 35863346
Immunity

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. [Abstract]

2020 Nov 17;53(5):1078-1094.e7. PMID: 33010224

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Immunity. 2020 Nov 17;53(5):1078-1094.e7. [Abstract]

Frequency of TdTomato-labelled cells in TdT-Jchain mice treated with Tamoxifen (mice; 50 mg/kg； oral gavage; for two consecutive days) 14 and 15 days after WNV vaccination was analyzed by flow cytometry 13 days later (28 days after WNV vaccination) and compared to week 1 labeling.
Cancer Commun (Lond)

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target. [Abstract]

2025 Oct 16. PMID: 41103012
Cancer Commun (Lond)

Yap methylation-induced FGL1 expression suppresses anti-tumor immunity and promotes tumor progression in KRAS-driven lung adenocarcinoma. [Abstract]

2024 Nov;44(11):1350-1373. PMID: 39340215
Gut

IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. [Abstract]

2023 May;72(5):821-833. PMID: 35613844
Cell Mol Immunol

SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation. [Abstract]

2026 May;23(5):471-490. PMID: 41922599
Cell Mol Immunol

An animal model of NLRC4-associated autoinflammation and infantile enterocolitis reveals novel therapeutic strategies. [Abstract]

2025 Oct 20. PMID: 41116055
Cell Mol Immunol

Demyelination-derived lysophosphatidylserine promotes microglial dysfunction and neuropathology in a mouse model of Alzheimer's disease. [Abstract]

2025 Feb;22(2):134-149. PMID: 39741193
Cell Mol Immunol

GPR34 senses demyelination to promote neuroinflammation and pathologies. [Abstract]

2024 Oct;21(10):1131-1144. PMID: 39030423
Nat Cell Biol

Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression. [Abstract]

2024 Dec;26(12):2099-2114. PMID: 39511379

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Dec;26(12):2099-2114. [Abstract]

Tamoxifen (2 mg/day; i.p.; for 5 consecutive days) can effectively induce the removal of NAT1 in various tissues, including muscle, white adipose tissue, pancreas, and liver, in adult Nat1^fl/fl;UBC^creERT2/+ mice and in Nat1^fl/fl;UBC^creERT2/+;Ripk1^D138N/D138N mice carrying a RIPK1 allele with an inactivation mutation.
Cancer Res

YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer. [Abstract]

2024 Nov 15;84(22):3728-3742. PMID: 39137404

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 15;84(22):3728-3742. [Abstract]

Schematic image of selective YAP1 depletion model on Cd248-CreERT2; Yap1flox/flox mice by using Tamoxifen (120 mg/kg/day; i.p. for 5 d).
Sci Bull

Nuclear receptor ESRRA promotes ERα-positive breast cancer through dual action on super enhancers and promoters to regulate gene transcriptional programs. [Abstract]

2025 Sep 29:S2095-9273(25)00984-3. PMID: 41111053
Nat Neurosci

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy. [Abstract]

2025 Jul;28(7):1404-1417. PMID: 40425792
Bone Res

Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome. [Abstract]

2024 Sep 6;12(1):53. PMID: 39242551
Autophagy

Mechanical stress-mediated ferritinophagy aggravates cartilage endplate degeneration via a PIEZO1-NCOA4-ZBP1 axis. [Abstract]

2026 May 31:1-22. PMID: 42153663
Autophagy

Inflammatory signaling attenuates spliceosome function and cognitive ability. [Abstract]

2025 Dec;21(12):3123-3141. PMID: 40963239
Nat Commun

Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy. [Abstract]

2025 Apr 30;16(1):4047. PMID: 40307212
Nat Commun

Oligodendrocyte precursor cells facilitate neuronal lysosome release. [Abstract]

2025 Jan 30;16(1):1175. PMID: 39885146
Nat Commun

Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments. [Abstract]

2024 Dec 30;15(1):10838. PMID: 39738060
Nat Commun

Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression. [Abstract]

2024 Nov 12;15(1):9770. PMID: 39532893
Nat Commun

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells. [Abstract]

2024 Oct 29;15(1):9337. PMID: 39472435
Nat Commun

Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases. [Abstract]

2024 Sep 6;15(1):7791. PMID: 39242637
Circ Res

Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension. [Abstract]

2025 Jan 17;136(2):e1-e19. PMID: 39655444
J Adv Res

SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo. [Abstract]

2025 Jul 12:S2090-1232(25)00545-4. PMID: 40659088
J Adv Res

GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis. [Abstract]

2025 Jul:73:501-515. PMID: 39103049
J Adv Res

Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx. [Abstract]

2022 Nov:41:63-75. PMID: 36328754
Neuron

Oligodendrocyte-encoded lactate dehydrogenase A couples glycolysis to remyelination via protein lactylation. [Abstract]

2026 Mar 16:S0896-6273(26)00137-6. PMID: 41844160
Sci Immunol

DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements. [Abstract]

2025 Sep 5;10(111):eadq0457. PMID: 40911696
Sci Immunol

Innate lymphoid cells originate from fetal liver-derived tissue-resident progenitors. [Abstract]

2025 Jul 11;10(109):eadu7962. PMID: 40644510
Redox Biol

Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model. [Abstract]

2022 Nov:57:102509. PMID: 36302319

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102509. [Abstract]

Expression of TFRC in primary fibroblasts from TFRCflox/flox and TFRC−/− mice was assessed by western blot after 5 days of Tamoxifen intraperitoneal injection and 7 days of waiting.
Nucleic Acids Res

Super-enhancer-controlled positive feedback loop BRD4/ERα-RET-ERα promotes ERα-positive breast cancer. [Abstract]

2022 Oct 14;50(18):10230-10248. PMID: 36124682
Theranostics

Cardiomyocyte-derived OTUD7B promotes cardiac hypertrophy by deubiquitinating SERCA2a. [Abstract]

2026 Feb 4;16(8):4452-4470. PMID: 41695487
Theranostics

Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction. [Abstract]

2024 Aug 1;14(11):4499-4518. PMID: 39113792
Theranostics

A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection. [Abstract]

2021 Sep 21;11(19):9623-9651. PMID: 34646390
Theranostics

Rbm24 modulates adult skeletal muscle regeneration via regulation of alternative splicing. [Abstract]

2020 Sep 11;10(24):11159-11177. PMID: 33042276
Theranostics

Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development. [Abstract]

2020 Aug 29;10(24):10874-10891. PMID: 33042259

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Aug 29;10(24):10874-10891. [Abstract]

Representative fields, intracellular TG contents and secreted TG of female C57BL/6 mice hepatocytes treated with C29, Tamoxifen (20 μM; 36 h), Toremifene and 4-OHT. LDs were labeled with Nile Red (red).

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Aug 29;10(24):10874-10891. [Abstract]

Representative images of liver tissue (top), sections stained with Oil Red O (bottom) and liver TG levels from Ad-ERRα or Ad-Ctrl-injected female mice treated with TMX (100 mg/kg; p.o. for 5 days).
Acta Pharm Sin B

2026 May 12.
Biomark Res

PAQR5 drives the malignant progression and shapes the immunosuppressive microenvironment of hepatocellular carcinoma by activating the NF-κB signaling. [Abstract]

2025 May 7;13(1):70. PMID: 40336138
J Clin Invest

Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury. [Abstract]

2026 Apr 2;136(12):e196112. PMID: 41926211
J Clin Invest

Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling. [Abstract]

2026 Mar 2;136(5):e196905. PMID: 41766668
J Clin Invest

Astrocyte-intrinsic signaling of chitinase-like protein CHI3L1 drives inflammation and amplifies demyelination in neuromyelitis optica. [Abstract]

2026 Jan 2;136(1):e195506. PMID: 41480772
J Clin Invest

Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness. [Abstract]

2025 Oct 16:e188822. PMID: 41100460
J Clin Invest

PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. [Abstract]

2025 Jun 2;135(11):e184158. PMID: 40454481
J Clin Invest

Inhibition of aortic CX3CR1+ macrophages mitigates thoracic aortic aneurysm progression in Marfan syndrome in mice. [Abstract]

2025 Jan 16;135(2):e178198. PMID: 39817456
J Exp Clin Cancer Res

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer. [Abstract]

2024 Jun 20;43(1):173. PMID: 38898487
Adv Sci (Weinh)

CD4+ Tregs Drive Post-Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation. [Abstract]

2026 May 20:e18564. PMID: 42159401
Adv Sci (Weinh)

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation. [Abstract]

2026 Feb;13(10):e17825. PMID: 41524160
Adv Sci (Weinh)

Piezo1 Upregulation in Monocyte-Derived Macrophages Impairs Post-Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis. [Abstract]

2025 Nov 10:e10991. PMID: 41214880
Adv Sci (Weinh)

Integrin α8-Mediated Pericyte Morphogenesis Controls Blood-Brain Barrier Integrity. [Abstract]

2025 Oct 14:e15374. PMID: 41085070
Adv Sci (Weinh)

Regulation of Neuroinflammation by Microglial DUBA-IRAK1-IKKβ Signaling Loop. [Abstract]

2025 Aug 4:e03972. PMID: 40755418
Adv Sci (Weinh)

Epigenetic Regulation of DAPK1 and Netrin-1 Drives Diabetic Encephalopathy. [Abstract]

2025 Aug 11:e02535. PMID: 40787892
Adv Sci (Weinh)

Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy. [Abstract]

2024 Aug;11(29):e2401676. PMID: 38837607
Cell Rep Med

CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. [Abstract]

2025 Apr 15;6(4):102053. PMID: 40187357
Sci Adv

Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles. [Abstract]

2026 Jun 12;12(24):eaed2731. PMID: 42284421
Sci Adv

ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome. [Abstract]

2024 Jul 5;10(27):eadm7373. PMID: 38959316
Sci Adv

Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury. [Abstract]

2024 Jul 19;10(29):eadp5239. PMID: 39028822
Sci Adv

Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome. [Abstract]

2024 Feb 2;10(5):eadj7813. PMID: 38306420
Sci Adv

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis. [Abstract]

2023 Sep;9(35):eadg7125. PMID: 37647391
Cell Death Differ

TUFT1 stabilizes TGF-β receptor II protein and facilitates activation of hepatic stellate cells into metastasis-promoting myofibroblasts. [Abstract]

2026 Jan 28. PMID: 41593321
Cell Death Differ

HDAC3 activates endothelial NLRP3 inflammasome and promotes atherosclerosis via inhibiting the acetylation of specificity protein 1. [Abstract]

2025 Nov 26. PMID: 41299088
Cell Death Differ

FMRP regulation of STAT3-MYC signaling is critical for adult hippocampal neurogenesis and cognitive flexibility. [Abstract]

2025 Jul 19. PMID: 40683950
Biomaterials

Black phosphorus nanosheets activate tumor immunity of glioblastoma by modulating the expression of the immunosuppressive molecule PD-L1. [Abstract]

2025 Jun:317:123062. PMID: 39736218
Research (Wash D C)

Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone-Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation. [Abstract]

2025 Feb 19:8:0619. PMID: 39975575
Cardiovasc Res

METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs. [Abstract]

2026 Mar 24:cvag069. PMID: 41873711
Chem Eng J

2026 Mar 19.
Cardiovasc Res

RBM24 regulates phenotypic switching of smooth muscle cell in vascular remodeling by stabilizing JAK2 mRNA. [Abstract]

2025 Nov 11:cvaf219. PMID: 41216933
Cardiovasc Res

YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in VSMCs. [Abstract]

2025 Aug 7:cvaf136. PMID: 40795179
Cardiovasc Res

METTL3-catalyzed m6A methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis. [Abstract]

2025 May 6;121(4):568-584. PMID: 39977233
Cardiovasc Res

Cardiomyocyte βII spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function. [Abstract]

2024 Sep 21;120(11):1312-1326. PMID: 38832923
Cell Death Dis

Endothelial IRE1 signaling maintains blood-brain barrier integrity and limits neuroinflammation after traumatic brain injury. [Abstract]

2026 Feb 9. PMID: 41663365
Cell Death Dis

RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion. [Abstract]

2025 Nov 30. PMID: 41318657
Cell Death Dis

ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy. [Abstract]

2025 Mar 25;16(1):201. PMID: 40133274
Cell Death Dis

Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy. [Abstract]

2023 Dec 5;14(12):796. PMID: 38052820
Cell Death Dis

Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice. [Abstract]

2021 Oct 26;12(11):1003. PMID: 34702801
Cancer Lett

JAML promotes the antitumor role of tumor-resident CD8+ T cells by facilitating their innate-like function in human lung cancer. [Abstract]

2024 May 28:590:216839. PMID: 38570084
Cancer Lett

DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion. [Abstract]

2024 Mar 1:584:216609. PMID: 38211648
Int J Biol Sci

The SGK3/GSK3β/β-catenin signaling promotes breast cancer stemness and confers resistance to alpelisib therapy. [Abstract]

2025 Mar 19;21(6):2462-2475. PMID: 40303291
Cell Commun Signal

Estrogen receptor α-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer. [Abstract]

2019 May 23;17(1):50. PMID: 31122254

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2019 May 23;17(1):50. [Abstract]

Tamoxifen inhibits the growth and metastasis of prostate tumors in vivo. Western blot analysis of the indicated proteins in prostate primary tumors tissues.
J Neuroinflammation

Hyperglycemia impairs microglia responding to retinal vasculopathy via enhanced norepinephrine-ADRB2 signaling. [Abstract]

2025 Dec 8. PMID: 41361454
J Neuroinflammation

Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation. [Abstract]

2025 Oct 31;22(1):253. PMID: 41174779
J Neuroinflammation

Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss. [Abstract]

2024 Nov 14;21(1):295. PMID: 39543619
Phytomedicine

Tongmai Huazheng mixture attenuates adenomyosis by inducing ferroptosis through suppression of the JAK2/STAT3 signaling pathway. [Abstract]

2026 Jan:150:157748. PMID: 41477983
Phytomedicine

Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition. [Abstract]

2024 May:127:155461. PMID: 38452697
Arch Toxicol

Fibroblast EGFR signaling mediates ricin toxin-induced acute lung injury via EGR1/CXCL1 axis. [Abstract]

2025 May 3. PMID: 40317338
J Hazard Mater

Fibroblast-derived CXCL14 aggravates crystalline silica-induced pulmonary fibrosis by mediating polarization and recruitment of interstitial macrophages. [Abstract]

2023 Oct 15:460:132489. PMID: 37688871
eGastroenterology

Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection. [Abstract]

2026 Mar 31;4(1):e100348. PMID: 41948149
Mol Psychiatry

Anterior insular cortex regulates depression-like and ASD-like behaviors via the differential contribution of two subsets of microglia. [Abstract]

2025 Aug 6. PMID: 40770435
Sci China Life Sci

Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease. [Abstract]

2025 Jul;68(7):2010-2027. PMID: 40347213
Proc Natl Acad Sci U S A

Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton. [Abstract]

2023 Jan 3;120(1):e2203779120. PMID: 36577075
Proc Natl Acad Sci U S A

Super-enhancers conserved within placental mammals maintain stem cell pluripotency. [Abstract]

2022 Oct 4;119(40):e2204716119. PMID: 36161929
Proc Natl Acad Sci U S A

DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects. [Abstract]

2021 Apr 27;118(17):e2024258118. PMID: 33879618
Dev Cell

A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma. [Abstract]

2025 Sep 3:S1534-5807(25)00530-1. PMID: 40930100
Dev Cell

FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation. [Abstract]

2024 Aug 19;59(16):2085-2100.e9. PMID: 38821057
Oncogene

PLK1-mediated PDHA1 phosphorylation drives metabolic reprogramming in lung cancer. [Abstract]

2025 Sep 16:10.1038/s41388-025-03571-1. PMID: 40957950
NPJ Breast Cancer

Modeling tumor relapse using proliferation tracing and ablation transgenic mouse. [Abstract]

2025 Jul 17;11(1):73. PMID: 40675988
NPJ Breast Cancer

Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models. [Abstract]

2022 Mar 10;8(1):31. PMID: 35273179
Mater Des

2025 Oct.
Clin Transl Med

Tamoxifen induces fatty liver disease in breast cancer through the MAPK8/FoxO pathway. [Abstract]

2020 Jan;10(1):137-150. PMID: 32508033

Tamoxifen Citrate purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2020 Jan;10(1):137-150. [Abstract]

Different transmission of MAPK8/FoxO signaling pathway in breast cancer cells (MCF-7, T47D, ZR-75, and MDA-MB-231) and liver cells (LO2) exposed to TAM (Tamoxifen).
Br J Cancer

Spatial molecular analyses reveal key features associated with response to KN026 in advanced HER2-positive breast cancer. [Abstract]

2025 Dec 9. PMID: 41366063
ACS Appl Mater Interfaces

A Self-Delivering Oxygen Modulator for Breast Cancer Immunotherapy via Pyroptosis Induction and PD-L1 Degradation. [Abstract]

2025 Aug 27;17(34):48029-48043. PMID: 40796528
Stem Cell Res Ther

Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX3CR1+ synovial lining macrophage barrier. [Abstract]

2025 Mar 5;16(1):111. PMID: 40038808
Br J Cancer

Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer. [Abstract]

2022 Sep;127(5):927-936. PMID: 35618789
Cell Rep

Calcium influx drives m6A-dependent RUNX1T1 splicing to promote adipogenic commitment. [Abstract]

2026 May 28;45(6):117471. PMID: 42213774
Cell Rep

Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling. [Abstract]

2025 Dec 11;44(12):116678. PMID: 41385373
Cell Rep

The xCT/CD98 complex suppresses ferroptosis in pan-cancer via a non-canonical RACK1-mediated iron homeostasis pathway. [Abstract]

2025 Nov 25;44(11):116563. PMID: 41252251
Cell Rep

Microglia mediated by LAG3 regulate astrocyte morphogenesis in the brain white matter. [Abstract]

2025 Aug 5;44(8):116112. PMID: 40773347
Cell Rep

Maternal phthalates exposure promotes neural stem cell differentiation into phagocytic astrocytes and synapse engulfment via IRE1α/XBP1s pathway. [Abstract]

2025 Jan 2;44(1):115126. PMID: 39752254
Cell Rep

Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus. [Abstract]

2024 May 10;43(5):114226. PMID: 38733586
Cell Rep

A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation. [Abstract]

2024 Feb 17;43(2):113804. PMID: 38368612
Cell Rep

RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis. [Abstract]

2024 Feb 15;43(2):113786. PMID: 38363684
Cell Rep

CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling. [Abstract]

2023 Sep 30;42(10):113202. PMID: 37777961
Cell Rep

FSHR-mTOR-HIF1 signaling alleviates mouse follicles from AMPK-induced atresia. [Abstract]

2023 Sep 19;42(10):113158. PMID: 37733588
Cell Prolif

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis. [Abstract]

2025 Dec 30:e70158. PMID: 41467312
Cell Prolif

MCL restrained ROS/AKT/ASAH1 pathway to therapy tamoxifen resistance breast cancer by stabilizing NRF2. [Abstract]

2024 Nov;57(11):e13700. PMID: 38924190
Cell Prolif

Type H vessel/platelet-derived growth factor receptor β+ perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage. [Abstract]

2023 Jul;56(7):e13406. PMID: 36694343
Cell Prolif

Direct inhibitory effect on viral entry of influenza A and SARS-CoV-2 viruses by azithromycin. [Abstract]

2021 Jan;54(1):e12953. PMID: 33211371
Transl Psychiatry

Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner. [Abstract]

2025 Aug 15;15(1):285. PMID: 40817224
Br J Pharmacol

Microglial forkhead box O3a deficiency attenuates LPS-induced neuro-inflammation and depressive-like behaviour through regulating the expression of peroxisome proliferator-activated receptor-γ. [Abstract]

2024 Oct;181(20):3908-3925. PMID: 38881194
Brain Behav Immun

An integral blood-brain barrier in adulthood relies on microglia-derived PDGFB. [Abstract]

2024 Jan:115:705-717. PMID: 37992789
J Med Chem

Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. [Abstract]

2020 Oct 8;63(19):11085-11099. PMID: 32886512
Atherosclerosis

Nicotine induces m6A-modified eNOS dysregulation to aggravate endothelial injury in male mice. [Abstract]

2025 Dec:411:120558. PMID: 41192190
Cancer Cell Int

Organoids as a model system for researching human neuroendocrine tumor of the breast. [Abstract]

2024 Dec 27;24(1):433. PMID: 39731167
Front Immunol

Development of a customizable mouse backbone spectral flow cytometry panel to delineate immune cell populations in normal and tumor tissues. [Abstract]

2024 Mar 27:15:1374943. PMID: 38605953
J Invest Dermatol

FOXE1 Contributes to the Development of Psoriasis by Regulating Wnt5a. [Abstract]

2023 Dec;143(12):2366-2377.e7. PMID: 37394057
Front Immunol

Analysis of Mononuclear Phagocytes Disclosed the Establishment Processes of Two Macrophage Subsets in the Adult Murine Kidney. [Abstract]

2022 Mar 10;13:805420. PMID: 35359928
Pharmaceutics

Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets. [Abstract]

2022 Jan 12;14(1):176. PMID: 35057070
J Ethnopharmacol

The modified Zuojin formula (SQQT) associates ILC2-linked JAK-2/STAT5/c-Myc cascade and gastric metaplasia regression. [Abstract]

2026 May 10:362:121345. PMID: 41663001
Neurosci Bull

Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice. [Abstract]

2026 Mar 22. PMID: 41866450
Neurosci Bull

Endothelial Cell Integrin α6 Regulates Vascular Remodeling Through the PI3K/Akt-eNOS-VEGFA Axis After Stroke. [Abstract]

2025 May 2. PMID: 40316875
J Ethnopharmacol

Combining transcriptomics and network pharmacology to reveal the mechanism of zuojin capsule improving spasmolytic polypeptide-expressing metaplasia. [Abstract]

2024 Jan 10;318(Pt B):117075. PMID: 37625606
CNS Neurosci Ther

SIX2-Mediated Microglial M2 Polarization and Exosomal miR-3470b Delivery Protect Dopaminergic Neurons in Parkinson's Disease. [Abstract]

2026 Feb;32(2):e70756. PMID: 41700504
Biochem Pharmacol

Targeting neuropilin-1 attenuates 4-hydroxytamoxifen-induced stemness and sensitizes ERα-re-expressing TNBC to tamoxifen. [Abstract]

2026 Jun 12;251(Pt 2):118163. PMID: 42285368
Biochem Pharmacol

Mutant NPM1-regulated estrogen signaling promotes leukemia cell survival by upregulating HGF and represents a therapeutic vulnerability. [Abstract]

2026 May:247:117796. PMID: 41679667
Biochem Pharmacol

TRPV4 maintains the contractile phenotype of VSMCs by regulating CPI-17. [Abstract]

2025 Oct:240:117107. PMID: 40619010
J Bone Miner Res

Single cell RNA sequencing shows that cells expressing Sox9 postnatally populate most skeletal lineages in mouse bone. [Abstract]

2025 Jun 3;40(6):799-812. PMID: 40143416
Biochem Pharmacol

MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway. [Abstract]

2024 Jul:225:116256. PMID: 38729448
Cell Mol Life Sci

Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc. [Abstract]

2024 Jan 22;81(1):49. PMID: 38252317
Cell Mol Life Sci

Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer. [Abstract]

2023 Mar 18;80(4):100. PMID: 36933062
Biochem Pharmacol

A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer. [Abstract]

2021 Jun:188:114583. PMID: 33915156
Life Sci

A protective role of ECSIT in chemotherapy-induced intestinal mucositis by maintaining Lgr5+ intestinal stem cells and gut homeostasis. [Abstract]

2026 Mar 15:389:124236. PMID: 41611204
Breast Cancer Res

UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5. [Abstract]

2024 Mar 11;26(1):44. PMID: 38468288
Transl Res

Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity. [Abstract]

2023 Jul:257:54-65. PMID: 36754276
Cells

A Comprehensive Adenoid Cystic Carcinoma-Derived Organoid Platform for Disease Modeling and Drug Screening Captures Interpatient Heterogeneity. [Abstract]

2026 Feb 23;15(4):383. PMID: 41744826
Biomacromolecules

Noncovalent Surface Locking of Mesoporous Silica Nanoparticles for Exceptionally High Hydrophobic Drug Loading and Enhanced Colloidal Stability. [Abstract]

2015 Sep 14;16(9):2701-14. PMID: 26200587
Pharmaceuticals (Basel)

Development and Application of an UPLC-MS/MS Method for Simultaneous Quantification of Abemaciclib and Tamoxifen with Their Active Metabolites in Rat Plasma: Application to a Pharmacokinetic Study. [Abstract]

2026 May 19;19(5):795. PMID: 42198468
Pharmaceuticals (Basel)

Refined Jianpi Huayu Jiedu Decoction Attenuates TAM-Induced Spasmolytic Polypeptide-Expressing Metaplasia (SPEM) by Modulating LCN2-Associated Mitochondrial Dysfunction. [Abstract]

2026 Apr 24;19(5):667. PMID: 42198341
Int Immunopharmacol

Hexokinase 2 deficiency protects against sepsis-associated lung injury via suppressing the NF-κB signaling pathway. [Abstract]

2026 Jun 20:185:117023. PMID: 42322859
Int Immunopharmacol

The immunoregulator β-glucan produces antidepressant effects through microglia-mobilized astrocytic P2Y1R-BDNF signaling in the dentate gyrus. [Abstract]

2025 Sep 6:165:115494. PMID: 40915186
Int J Mol Sci

HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations. [Abstract]

2025 Jul 9;26(14):6593. PMID: 40724844
Int Immunopharmacol

ATP citrate lyase ablation hampers exocrine regeneration via TLR4/NF-kappaB signaling after acute pancreatitis in mice. [Abstract]

2024 Oct 31;143(Pt 3):113485. PMID: 39486178
Int J Mol Sci

Tamoxifen Exerts Anticancer Effects on Pituitary Adenoma Progression via Inducing Cell Apoptosis and Inhibiting Cell Migration. [Abstract]

2022 Feb 28;23(5):2664. PMID: 35269804
Glia

Targeted Inhibition of MEGF10-Mediated Astrogliosis Reduces Glial Scar Formation and Promotes Neurofunction Recovery in Mice After Stroke. [Abstract]

2026 Jun;74(6):e70159. PMID: 41999081
Glia

Acid-Sensing PAC Channel Promotes Astrocyte Acidosis in Ischemic Stroke. [Abstract]

2025 Jul 28. PMID: 40719051
Glia

HK2 in microglia and macrophages contribute to the development of neuropathic pain. [Abstract]

2024 Feb;72(2):396-410. PMID: 37909251
mBio

Genome-Wide CRISPR-Cas9 Screen Identifies SMCHD1 as a Restriction Factor for Herpesviruses. [Abstract]

2023 Apr 25;14(2):e0054923. PMID: 37010434
J Clin Endocrinol Metab

Organoid Cultures Derived From Patients With Papillary Thyroid Cancer. [Abstract]

2021 Apr 23;106(5):1410-1426. PMID: 33524147
Chem Biol Interact

Vitamin D inhibits tamoxifen-induced non-alcoholic fatty liver disease through a nonclassical estrogen receptor/liver X receptor pathway. [Abstract]

2024 Feb 1:389:110865. PMID: 38191086
Chem Biol Interact

Fatostatin inhibits SREBP2-mediated cholesterol uptake via LDLR against selective estrogen receptor α modulator-induced hepatic lipid accumulation. [Abstract]

2022 Sep 25:365:110091. PMID: 35944649
Bioorg Chem

A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer. [Abstract]

2026 Jun 18:180:110129. PMID: 42348942
Exp Gerontol

Hepcidin inhibits osteoclast differentiation to alleviate osteoporosis by modulating the p53/miR-34a/Trem2 axis. [Abstract]

2026 Jan:213:112994. PMID: 41386388
Mol Med Rep

Mechanotransducer Piezo1 drives ventilator‑induced lung injury in lung epithelial cells via the calcineurin/NFATc3 pathway. [Abstract]

2026 Jun;33(6):183. PMID: 42059278
PLoS Pathog

CK2 derived from brain microvascular endothelial cells induces astrocyte inflammatory response in Escherichia coli-induced meningitis. [Abstract]

2025 Sep 10;21(9):e1013464. PMID: 40929057
Sci Rep

Impact of prenatal Di(2-ethylhexyl) phthalate exposure on pubertal development in female offspring rats: A focus on ERα-Mediated IGF-1/NKB crosstalk in the hypothalamus. [Abstract]

2025 Jul 1;15(1):22255. PMID: 40595203
PLoS Pathog

Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy. [Abstract]

2025 Apr 10;21(4):e1013052. PMID: 40208866
Exp Neurol

Oligodendrocyte lineage cell-specific GPR17/Gelsolin signaling regulates remyelination and cognitive recovery after subarachnoid hemorrhage. [Abstract]

2026 Sep:403:115819. PMID: 42107622
Neoplasia

SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer. [Abstract]

2025 Mar:61:101125. PMID: 39904115
Cancers (Basel)

BRD4 Inhibition as a Strategy to Prolong the Response to Standard of Care in Estrogen Receptor-Positive Breast Cancer. [Abstract]

2023 Aug 11;15(16):4066. PMID: 37627092
Cancers (Basel)

Loss of cIAP1 in Endothelial Cells Limits Metastatic Extravasation through Tumor-Derived Lymphotoxin Alpha. [Abstract]

2021 Feb 3;13(4):599. PMID: 33546280
Neuropharmacology

GPR139-mediated cholinergic circuit from the medial septum to the ventral hippocampal CA3 modulates cognitive impairment in Alzheimer's disease. [Abstract]

2026 Nov 1:298:111043. PMID: 42218995
Med Oncol

Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway. [Abstract]

2025 Jul 21;42(8):358. PMID: 40691672
Mol Cell Biochem

Endothelium Piezo1 deletion alleviates experimental varicose veins by attenuating perivenous inflammation. [Abstract]

2025 Apr;480(4):2423-2435. PMID: 39249600
Cell Signal

Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-κB signaling pathway. [Abstract]

2024 May:117:111080. PMID: 38320624
J Cell Mol Med

Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1. [Abstract]

2024 Jan;28(1):e18007. PMID: 37890842
J Cell Mol Med

Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer. [Abstract]

2020 Jan;24(2):1599-1613. PMID: 31782270
Aquat Toxicol

Is acyl-CoA cholesterol acyltransferase 2 the enzyme responsible for the esterification of okadaic acid in bivalves?. [Abstract]

2026 Jun:295:107814. PMID: 41935504
Biomedicines

Caveolin-1 Modulates Islet Amyloid Polypeptide Expression Through Interaction with TXNIP in Murine Pancreatic β-Cells. [Abstract]

2026 Jun 15;14(6):1344. PMID: 42351772
iScience

Cardiac mural cells are rate-limiting for coronary vascularization after heart injury. [Abstract]

2025 Sep 10;28(10):113536. PMID: 41069851
J Neurosci

A Light-Responsive Neural Circuit Suppresses Feeding. [Abstract]

2024 Jul 24;44(30):e2192232024. PMID: 38897723
Prog Neuropsychopharmacol Biol Psychiatry

Microglial HMGB2 mediates neuroinflammation and brain damage in Cx3cr1-creERT2 epileptic mice through astrocyte-derived CCL2. [Abstract]

2026 Jun 20:147:111763. PMID: 42218973
Appl Biol Chem

2026 Jun 24;69(1):36.
Neurobiol Stress

Microglial SIRT6 confers protection against neuroinflammation-associated depression through NRF2-HO1 signaling. [Abstract]

2026 Mar 21:42:100804. PMID: 41938092
J Biol Chem

Caveolin-1 deficiency improved glucose metabolism via modulation of β-cell autophagy in high-fat diet-fed mice. [Abstract]

2026 Jun;302(6):111480. PMID: 42031171
J Biol Chem

Downregulation of the splicing regulator NSRP1 confers resistance to CDK4/6 inhibitors via activation of interferon signaling in breast cancer. [Abstract]

2025 Jan;301(1):108070. PMID: 39667501
RNA Biol

Rbm24 regulates inner-ear-specific alternative splicing and is essential for maintaining auditory and motor coordination. [Abstract]

2021 Apr;18(4):468-480. PMID: 32887533
Naunyn Schmiedebergs Arch Pharmacol

ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen. [Abstract]

2025 May 28. PMID: 40425765
Naunyn Schmiedebergs Arch Pharmacol

Overexpression of KIF2C amplifies tamoxifen resistance and lung metastasis of breast cancer through PLK1/C-Myc pathway. [Abstract]

2025 Mar 18. PMID: 40100379
JOR Spine

PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis. [Abstract]

2025 Nov 4;8(4):e70133. PMID: 41194970
Viruses

Autophagy Deregulation in HIV-1-Infected Cells Increases Extracellular Vesicle Release and Contributes to TLR3 Activation. [Abstract]

2024 Apr 20;16(4):643. PMID: 38675983
Biotechnol J

Engineering a Membrane-Anchored CreER Recombinase With Reduced Basal Activity for In Vitro Recombination. [Abstract]

2026 May;21(5):e70236. PMID: 42116754
Cardiovasc Drugs Ther

E3 Ubiquitin Ligase UBR5 Aggravates Cardiac Hypertrophy Via Inhibiting Nrf2/HO-1 Pathway. [Abstract]

2026 Mar 13. PMID: 41824182
Int J Biochem Cell Biol

Tamoxifen upregulates the peroxisomal β-oxidation enzyme Enoyl CoA hydratase and 3-hydroxyacyl CoA hydratase ameliorating hepatic lipid accumulation in mice. [Abstract]

2024 Jul:172:106585. PMID: 38734232
Cardiovasc Drugs Ther

Calsyntenin-1 Promotes Doxorubicin-induced Dilated Cardiomyopathy in Rats. [Abstract]

2024 Apr;38(2):237-252. PMID: 36350487
Bioorg Med Chem

A novel selective estrogen receptor degrader induces cell cycle arrest in breast cancer via ERα degradation and the autophagy-lysosome pathway. [Abstract]

2023 Mar 15:82:117235. PMID: 36905762
J Pharm Biomed Anal

Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]

2021 Feb 20:195:113870. PMID: 33453569
Breast Cancer Res Treat

Monopolar spindle 1 contributes to tamoxifen resistance in breast cancer through phosphorylation of estrogen receptor α. [Abstract]

2023 Dec;202(3):595-606. PMID: 37695401
Chin J Integr Med

Curcumin Inhibits Fibroblast Differentiation and Epithelial-Mesenchymal Transition to Alleviate Adenomyosis through TGF-β1/Smad3 Pathway. [Abstract]

2026 Jan 15. PMID: 41540162
Oral Dis

DDX5 Alleviates Temporomandibular Joint Osteoarthritis via TNF-Induced NF-κB Signaling Pathway. [Abstract]

2025 Jul;31(7):2229-2242. PMID: 40013619
J Steroid Biochem Mol Biol

OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer. [Abstract]

2024 Nov:244:106599. PMID: 39147211
Hear Res

Chromatin and genomic instability in the cochlea contributing to age-related hearing loss: Insights from in vitro and in vivo models. [Abstract]

2026 Aug:478:109691. PMID: 42263393
Front Genet

Genome-wide analysis of the FOXA1 transcriptional regulatory network identifies super enhancer associated LncRNAs in tamoxifen resistance. [Abstract]

2022 Sep 20:13:992444. PMID: 36204307
Biochim Biophys Acta Gen Subj

MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production. [Abstract]

2023 Sep;1867(9):130413. PMID: 37331409
Toxicol Res (Camb)

Tamoxifen induced hepatic steatosis in high-fat feeding rats through SIRT1-Foxo1 suppression and LXR-SREBP1c activation. [Abstract]

2022 Jul 22;11(4):673-682. PMID: 36051666
PLoS One

Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expression. [Abstract]

2025 Jul 28;20(7):e0328698. PMID: 40720499
Biochem Biophys Res Commun

Tamoxifen promotes myogenic differentiation and skeletal muscle regeneration via activation of the GRP94. [Abstract]

2026 Aug 20:827:154022. PMID: 42208231
Biochem Biophys Res Commun

SHED aggregation-released extracellular vesicles rejuvenate Gli1+ cells and improve diabetic wound healing. [Abstract]

2025 Sep 1:777:152327. PMID: 40651366
Biochem Biophys Res Commun

Neutrophils suppress osteogenic differentiation of Gli1+ stem cells via neutrophil extracellular traps and contribute to bone loss in periodontitis. [Abstract]

2024 Dec 10:737:150916. PMID: 39489114
J Chromatogr B Analyt Technol Biomed Life Sci

Simultaneous determination of 11 oral targeted antineoplastic drugs and 2 active metabolites by LC-MS/MS in human plasma and its application to therapeutic drug monitoring in cancer patients. [Abstract]

2024 Apr 15:1237:124100. PMID: 38547701
Biochem Biophys Res Commun

Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]

2020 Feb 19;522(4):862-868. PMID: 31806372
Pharmacol Biochem Behav

Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus. [Abstract]

2025 Dec:257:174114. PMID: 41106438
Oncol Lett

Functional analysis of the effects of propofol on tamoxifen‑resistant breast cancer cells: Insights into transcriptional regulation. [Abstract]

2025 Feb 21;29(4):194. PMID: 40041408
Am J Transl Res

Evaluation of the safety and tolerability of tamoxifen for ischemia-incited renal injury in mice. [Abstract]

2018 Jul 15;10(7):2184-2194. PMID: 30093955
Res Sq

2026 Jun 2.
bioRxiv

2026 May 21.
Res Sq

2026 Feb 2.
Res Sq

2026 Feb 23.
SSRN

2025 Nov 6.
SSRN

2025 Sep 30.
SSRN

2025 Oct 13.
bioRxiv

2025 Oct 6.
bioRxiv

Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage. [Abstract]

2025 Oct 14:2025.10.12.681919. PMID: 41279276
bioRxiv

Controlled Delivery of a Neurotrophic Factor in the Adult Mouse Brain Using Engineered Microglia. [Abstract]

2025 Oct 7:2025.10.06.680702. PMID: 41279766
Cureus

Hsa-miR-181a-5p Enhances the Chemosensitivity of Breast Cancer Cells to Tamoxifen by Regulation of the OSBPL3/RAS Signaling Pathway. [Abstract]

2025 Oct 20;17(10):e94996. PMID: 41267704
bioRxiv

2025 Jun 17.
bioRxiv

2025 February 23.
Res Sq

2024 Oct 16.
Res Sq

2024 Aug 26.
Patent

US20240217988A1.
bioRxiv

2024 August 04.
Res Sq

2024 Jun 04.
Heliyon

Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer. [Abstract]

2024 Jun 14;10(12):e33104. PMID: 39022050
SSRN

2024 Mar 26.
SSRN

2024 Jan 10.
Journal of the Institute of Science and Technology

2023 Mar 3, 13(4), 2997-3006.
bioRxiv

2023 Dec 18.
bioRxiv

2023 Aug 22.
Research Square Preprint

2023 Aug 7.
bioRxiv

2023 Jun 22.
bioRxiv

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization. [Abstract]

2023 Mar 15:2023.03.14.532677. PMID: 36993187
bioRxiv

2023 Feb 7.
bioRxiv

2023 Jan 31.
Universität Basel

2022.
Research Square Preprint

2022 May.
Research Square Preprint

2022 May.
Research Square Preprint

2021 Oct.
Res Sq

Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19. [Abstract]

2020 Dec 31:rs.3.rs-100914. PMID: 33173861
bioRxiv

2020 Mar.
Chemosphere

Tamoxifen-induced hepatotoxicity via lipid accumulation and inflammation in zebrafish. [Abstract]

2020 Jan:239:124705. PMID: 31479913

Solvente y solubilidad

In Vitro:

DMSO : 50 mg/mL (88.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 10 mg/mL (17.74 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7742 mL

8.8709 mL

17.7418 mL

5 mM

0.3548 mL

1.7742 mL

3.5484 mL

10 mM

0.1774 mL

0.8871 mL

1.7742 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Protocolo

Animal Administration^[3]

Mice^[3]
Seven-week old TmcsMed1^-/- mice and the wild-type littermates are then administered Tamoxifen intraperitoneally at a daily dose of 65 mg/kg body weight for 5 days and then killed at selected intervals after initiation of Tamoxifen treatment. For each experiment 3 to 5 mice for control and csMed1^-/- are used. To obtain survival curve 41 csMed1^-/- and 41 csMed1^fl/fl mice are used. Thirteen TmcsMed^-/- mice and the same number of littermates are used for the survival curve experiments using Tamoxifen inducible model.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (296 KB)
SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18. [Content Brief]

[2]. Hawariah A, et al. In vitro response of human breast cancer cell lines to the growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity. Anticancer Res. 1998 Nov-Dec;18(6A):4383-6. [Content Brief]

[3]. Jia Y, et al. Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal DilatedCardiomyopathy in Mice. PLoS One. 2016 Aug 22;11(8):e0160755. [Content Brief]

[4]. Zhao R, et al. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. PLoS One. 2010 Apr 1;5(4):e9934. [Content Brief]

[5]. Laura Cooper, et al. Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. J Med Chem. 2020 Sep 4. [Content Brief]

[6]. Feil S, et, al. Inducible Cre mice. Methods Mol Biol. 2009;530:343-63. [Content Brief]

[7]. Bi Q, et al. Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension. Immunity. 2022 Aug 9;55(8):1466-1482.e9. [Content Brief]

[8]. Chen MY, et al. A review of tamoxifen administration regimen optimization for Cre/loxp system in mouse bone study. Biomed Pharmacother. 2023 Sep;165:115045. [Content Brief]

[9]. El-Beshbishy HA. Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. J Biochem Mol Biol. 2005 Sep 30;38(5):563-70. [Content Brief]

[10]. El-Beshbishy H A. The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen-induced liver injury in rats: DDB use is curative or protective[J]. BMB Reports, 2005, 38(3): 300-306. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	1.7742 mL	8.8709 mL	17.7418 mL	44.3546 mL
	5 mM	0.3548 mL	1.7742 mL	3.5484 mL	8.8709 mL
	10 mM	0.1774 mL	0.8871 mL	1.7742 mL	4.4355 mL
	15 mM	0.1183 mL	0.5914 mL	1.1828 mL	2.9570 mL
DMSO	20 mM	0.0887 mL	0.4435 mL	0.8871 mL	2.2177 mL
	25 mM	0.0710 mL	0.3548 mL	0.7097 mL	1.7742 mL
	30 mM	0.0591 mL	0.2957 mL	0.5914 mL	1.4785 mL
	40 mM	0.0444 mL	0.2218 mL	0.4435 mL	1.1089 mL
	50 mM	0.0355 mL	0.1774 mL	0.3548 mL	0.8871 mL
	60 mM	0.0296 mL	0.1478 mL	0.2957 mL	0.7392 mL
	80 mM	0.0222 mL	0.1109 mL	0.2218 mL	0.5544 mL

Tamoxifen Citrate

259 Cited Publications

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Tamoxifen Citrate

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Chemical Information

Publications (259)

Solvente y solubilidad

Protocolo

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

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