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  3. Tamoxifen Citrate

Tamoxifen Citrate (Synonyms: ICI 46474; Z-Tamoxifen Citrate; trans-Tamoxifen Citrate)

Cat. No.: HY-13757 Purity: >99.0%
Handling Instructions

Tamoxifen Citrate (ICI 46474) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity.

For research use only. We do not sell to patients.

Tamoxifen Citrate Chemical Structure

Tamoxifen Citrate Chemical Structure

CAS No. : 54965-24-1

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Tamoxifen Citrate:

Top Publications Citing Use of Products

    Tamoxifen Citrate purchased from MCE. Usage Cited in: Cell Commun Signal. 2019 May 23;17(1):50.

    Tamoxifen inhibits the growth and metastasis of prostate tumors in vivo. Western blot analysis of the indicated proteins in prostate primary tumors tissues.

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    Description

    Tamoxifen Citrate (ICI 46474) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[4].

    IC50 & Target

    Estrogen receptor

     

    HSP90

     

    In Vitro

    Tamoxifen Citrate (ICI 46474) shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2].

    In Vivo

    The Tamoxifen Citrate-inducible gene knockout strategy has clear advantages in that expression of a gene can be ablated in adult mice at will in a tissue specific manner. To study the role of Med1 in adult heart, 7-week old TmcsMed1-/- mice are given a daily Iintraperitoneal injection of Tamoxifen Citrate at a dose of 65 mg/kg for 5 days and killed at selected intervals thereafter. qPCR analysis of RNA shows that the Med1 expression begin to decrease after 3 days of Tamoxifen Citrate injection (about 70% decrease), and by 5 days of injection, Med1 expression is almost non-detectable in the heart. Tamoxifen Citrate-inducible cardiac-specific disruption of Med1 (TmcsMed1-/-) in adult mice causes dilated cardiomyopathy[3].

    Clinical Trial
    Molecular Weight

    563.64

    Formula

    C₃₂H₃₇NO₈

    CAS No.

    54965-24-1

    SMILES

    CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 500 mg/mL (887.09 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7742 mL 8.8709 mL 17.7418 mL
    5 mM 0.3548 mL 1.7742 mL 3.5484 mL
    10 mM 0.1774 mL 0.8871 mL 1.7742 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Animal Administration
    [3]

    Mice[3]
    Seven-week old TmcsMed1-/- mice and the wild-type littermates are then administered Tamoxifen intraperitoneally at a daily dose of 65 mg/kg body weight for 5 days and then killed at selected intervals after initiation of Tamoxifen treatment. For each experiment 3 to 5 mice for control and csMed1-/- are used. To obtain survival curve 41 csMed1-/- and 41 csMed1fl/fl mice are used. Thirteen TmcsMed-/- mice and the same number of littermates are used for the survival curve experiments using Tamoxifen inducible model. The specific criteria for animal euthanasia included absence of food or water intake, slow or no mobility, weak or absence of heart beat, absence of palpitation of the chest as well as absence of respiratory movement. Mice are euthanized by intraperitoneal pentobarbital injection at the dose of 150mg/kg body weight to minimize suffering.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: >99.0%

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    Keywords:

    TamoxifenICI 46474Z-Tamoxifentrans-TamoxifenICI46474ICI-46474Estrogen Receptor/ERRHSPAutophagyApoptosisHeat shock proteinsInhibitorinhibitorinhibit

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    Cat. No.:
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