E3 Ubiquitin Ligase UBR5 Aggravates Cardiac Hypertrophy Via Inhibiting Nrf2/HO-1 Pathway

  • Cardiovasc Drugs Ther. 2026 Mar 13. doi: 10.1007/s10557-026-07852-z.
Guofeng Zhu  1 ,  Haiyang Fang  2 ,  Congcong Xu  2 ,  Kai Zhu  2 ,  Tieqiu Huang  2 ,  Wei Zhou  3 ,  Min Huang  4
Affiliations
  • 1. Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • 2. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • 3. Department of Vascular and Interventional Radiology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • 4. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China. [email protected].
PMID: 41824182 DOI: 10.1007/s10557-026-07852-z
Keywords
Cardiac hypertrophy; HO-1; Nrf2; UBR5; Ubiquitination.
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