2. Membrane Transporter/Ion Channel
  3. Monoamine Transporter
  4. Radafaxine hydrochloride

Radafaxine hydrochloride  (Synonyms: GW-353162A; BW-306U)

Cat. No.: HY-17590 Purity: 99.01%
COA Handling Instructions

Radafaxine hydrochloride (GW-353162A) is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

For research use only. We do not sell to patients.

Radafaxine hydrochloride Chemical Structure

Radafaxine hydrochloride Chemical Structure

CAS No. : 106083-71-0

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 112 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 112 In-stock
Solid
5 mg USD 102 In-stock
10 mg USD 192 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Radafaxine hydrochloride (GW-353162A) is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. Radafaxine hydrochloride (GW-353162A) is a potent metabolite of bupropion and selective for inhibiting the reuptake of norepinephrine over dopamine[1][2][3].

In Vitro

The relatively low potency of Radafaxine hydrochloride (GW-353162A) in blocking DAT and its slow blockade suggests that it is unlikely to have reinforcing effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

292.20

Appearance

Solid

Formula

C13H19Cl2NO2
CAS No.
SMILES

O[[email protected]]1(C2=CC=CC(Cl)=C2)[[email protected]](C)NC(C)(C)CO1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (114.07 mM; Need ultrasonic)

DMSO : 25 mg/mL (85.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4223 mL 17.1116 mL 34.2231 mL
5 mM 0.6845 mL 3.4223 mL 6.8446 mL
10 mM 0.3422 mL 1.7112 mL 3.4223 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 8.33 mg/mL (28.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Radafaxine106083-71-0GW-353162A BW-306UMonoamine TransporterInhibitorinhibitorinhibit

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