2. Membrane Transporter/Ion Channel
  3. Monoamine Transporter
  4. FFN511

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices.

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FFN511 Chemical Structure

FFN511 Chemical Structure

CAS No. : 1004548-96-2

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Based on 1 publication(s) in Google Scholar

FFN511 Related Antibodies

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Description

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2].

In Vitro

FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FFN511 Related Antibodies

Cell Viability Assay[1]

Cell Line: mouse chromaffin cells
Concentration: 350 nM
Incubation Time: 30 min
Result: Accumulated in cultured mouse chromaffin cells (the same as LDCVs), and the accumulation could be abolished by the lipophilic base chloroquine, which collapses the vesicle pH gradient.
Molecular Weight

284.35

Formula

C17H20N2O2
CAS No.
SMILES

O=C1C=C(CCN)C2=CC3=C4N(CCC3)CCCC4=C2O1
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Purity & Documentation
References
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FFN511 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FFN5111004548-96-2FFN 511FFN-511Monoamine Transporterdopamine releaseneurotransmitteroptical tracercortical-striatalacute sliceschromaffin cellsInhibitorinhibitorinhibit

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