53179-07-0
53179-07-0
Chemical Structure
Nisoxetine
- CAS. Nr.: 53179-07-0
- Formula:C17H21NO2
- Molecular Weight:271.35
IUPAC Name: 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
InChIKey: ITJNARMNRKSWTA-UHFFFAOYSA-N
SMILES: CNCCC(OC1=CC=CC=C1OC)C2=CC=CC=C2
Biological Activity: Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].
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Nisoxetine | 98.56% | Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels. | ||||||||||||||||||||
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Nisoxetine (Standard) | ≥98% | Nisoxetine (Standard) is the analytical standard of Nisoxetine. This product is intended for research and analytical applications. Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels. | ||||||||||||||||||||
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References
- [1]. Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349(1): 129-32. [Content Brief]
- [2]. Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35(1): 63-70. [Content Brief]
- [3]. Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65(2): 350-7. [Content Brief]
Keywords
