1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. Adrenergic Receptor Calcium Channel
  3. Bevantolol hydrochloride

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist.

For research use only. We do not sell to patients.

Bevantolol hydrochloride Chemical Structure

Bevantolol hydrochloride Chemical Structure

CAS No. : 42864-78-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 30 In-stock
Solution
10 mM * 1 mL in DMSO USD 30 In-stock
Solid
5 mg USD 28 In-stock
10 mg USD 42 In-stock
25 mg USD 85 In-stock
50 mg USD 136 In-stock
100 mg USD 217 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].

IC50 & Target[1][2]

α adrenergic receptor

 

β adrenergic receptor

 

In Vitro

Bevantolol hydrochloride has a pKi of 6.23 for β2-adrenergic receptor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bevantolol hydrochloride (200 mg/kg; PO by water; for 6 weeks) produces a significant decrease in the expression level of β1 adrenoceptor mRNA[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g[2]
Dosage: 200 mg/kg
Administration: PO by water; for 6 weeks
Result: Produced a significant decrease in the expression level of β1 adrenoceptor mRNA.
Molecular Weight

381.89

Formula

C20H28ClNO4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CNCCC1=CC=C(C(OC)=C1)OC)COC2=CC=CC(C)=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (163.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 4.55 mg/mL (11.91 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6186 mL 13.0928 mL 26.1855 mL
5 mM 0.5237 mL 2.6186 mL 5.2371 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 6.25 mg/mL (16.37 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.6186 mL 13.0928 mL 26.1855 mL 65.4639 mL
5 mM 0.5237 mL 2.6186 mL 5.2371 mL 13.0928 mL
10 mM 0.2619 mL 1.3093 mL 2.6186 mL 6.5464 mL
DMSO 15 mM 0.1746 mL 0.8729 mL 1.7457 mL 4.3643 mL
20 mM 0.1309 mL 0.6546 mL 1.3093 mL 3.2732 mL
25 mM 0.1047 mL 0.5237 mL 1.0474 mL 2.6186 mL
30 mM 0.0873 mL 0.4364 mL 0.8729 mL 2.1821 mL
40 mM 0.0655 mL 0.3273 mL 0.6546 mL 1.6366 mL
50 mM 0.0524 mL 0.2619 mL 0.5237 mL 1.3093 mL
60 mM 0.0436 mL 0.2182 mL 0.4364 mL 1.0911 mL
80 mM 0.0327 mL 0.1637 mL 0.3273 mL 0.8183 mL
100 mM 0.0262 mL 0.1309 mL 0.2619 mL 0.6546 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Bevantolol hydrochloride
Cat. No.:
HY-121186
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