1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Adrenergic Receptor
    Calcium Channel
  3. Bevantolol hydrochloride

Bevantolol hydrochloride 

Cat. No.: HY-121186 Purity: >98.0%
Handling Instructions

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist.

For research use only. We do not sell to patients.

Bevantolol hydrochloride Chemical Structure

Bevantolol hydrochloride Chemical Structure

CAS No. : 42864-78-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 94 In-stock
Estimated Time of Arrival: December 31
25 mg USD 85 In-stock
Estimated Time of Arrival: December 31
50 mg USD 136 In-stock
Estimated Time of Arrival: December 31
100 mg USD 217 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].

IC50 & Target

pKi: 7.83 (β1-adrenergic receptor), 6.9 (α1-adrenergic receptor), 6.23 (β2-adrenergic receptor) and Ca2+[1][2]

In Vitro

Bevantolol hydrochloride has a pKi of 6.23 for β2-adrenergic receptor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bevantolol hydrochloride (200 mg/kg; PO by water; for 6 weeks) produces a significant decrease in the expression level of β1 adrenoceptor mRNA[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g[2]
Dosage: 200 mg/kg
Administration: PO by water; for 6 weeks
Result: Produced a significant decrease in the expression level of β1 adrenoceptor mRNA.
Molecular Weight

381.89

Formula

C₂₀H₂₈ClNO₄

CAS No.

42864-78-8

SMILES

OC(CNCCC1=CC=C(C(OC)=C1)OC)COC2=CC=CC(C)=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (163.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6186 mL 13.0928 mL 26.1855 mL
5 mM 0.5237 mL 2.6186 mL 5.2371 mL
10 mM 0.2619 mL 1.3093 mL 2.6186 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BevantololAdrenergic ReceptorCalcium ChannelBeta ReceptorCa2+ channelsCa channelsβ1α1cerebralcortexInhibitorinhibitorinhibit

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Product Name:
Bevantolol hydrochloride
Cat. No.:
HY-121186
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