2. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  3. Adrenergic Receptor
    Calcium Channel
  4. Bevantolol hydrochloride

Bevantolol hydrochloride 

Cat. No.: HY-121186 Purity: 98.98%
COA Handling Instructions

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist.

For research use only. We do not sell to patients.

Bevantolol hydrochloride Chemical Structure

Bevantolol hydrochloride Chemical Structure

CAS No. : 42864-78-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 94 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 94 In-stock
Solid
25 mg USD 85 In-stock
50 mg USD 136 In-stock
100 mg USD 217 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Bevantolol hydrochloride:

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].

IC50 & Target[1][2]

α adrenergic receptor

 

β adrenergic receptor

 

In Vitro

Bevantolol hydrochloride has a pKi of 6.23 for β2-adrenergic receptor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Bevantolol hydrochloride (200 mg/kg; PO by water; for 6 weeks) produces a significant decrease in the expression level of β1 adrenoceptor mRNA[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g[2]
Dosage: 200 mg/kg
Administration: PO by water; for 6 weeks
Result: Produced a significant decrease in the expression level of β1 adrenoceptor mRNA.
Molecular Weight

381.89

Appearance

Solid

Formula

C20H28ClNO4
CAS No.
SMILES

OC(CNCCC1=CC=C(C(OC)=C1)OC)COC2=CC=CC(C)=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (163.66 mM; Need ultrasonic)

H2O : 4.55 mg/mL (11.91 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6186 mL 13.0928 mL 26.1855 mL
5 mM 0.5237 mL 2.6186 mL 5.2371 mL
10 mM 0.2619 mL 1.3093 mL 2.6186 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 6.25 mg/mL (16.37 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MCE.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Bevantolol42864-78-8Adrenergic ReceptorCalcium ChannelBeta ReceptorCa2+ channelsCa channelsβ1α1cerebralcortexInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Bevantolol hydrochloride
Cat. No.:
HY-121186
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email address *

Phone number

 

Department *

Organization name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.