FFN246 

FFN246 is a fluorescent, dual substrate of serotonin transporter (SERT) probe and vesicular monoamine transporter 2 (VMAT2) with excitation and emission spectra 392/427 nm. FFN246 can be used for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation^[1].

FFN246 (2.5-20 μM, 30 mins) can be used for direct examination of serotonin transporter (SERT) activity and SERT inhibitors in 96-well cell culture assays, as well as specific labeling of serotonergic neurons of the dorsal raphe nucleus in the living tissue of acute mouse brain slices^[1].
FFN246 (20 μM, 30 mins) effectively traces serotonin uptake and packaging in the soma of serotonergic neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

256.27

C₁₅H₁₃FN₂O

2210244-83-8

O=C1C2=CC(CCN)=CC=C2NC3=C1C(F)=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Henke A, et al. Toward Serotonin Fluorescent False Neurotransmitters: Development of Fluorescent Dual Serotonin and Vesicular Monoamine Transporter Substrates for Visualizing Serotonin Neurons. ACS Chem Neurosci. 2018;9(5):925-934.  [Content Brief]