524-38-9
Chemical Structure
N-Hydroxyphthalimide
- CAS No.: 524-38-9
- Formula:C8H5NO3
- Molecular Weight:163.13
IUPAC Name: 2-hydroxyisoindoline-1,3-dione
InChIKey: CFMZSMGAMPBRBE-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(N1O)=O)C=CC=C2
Biological Activity: N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer[1][2][3].
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N-Hydroxyphthalimide | 99.63% | N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer. | ||||||||||||||||||||
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N-Hydroxyphthalimide (Standard) | ≥98% | N-Hydroxyphthalimide (Standard) is the analytical standard of N-Hydroxyphthalimide (HY-Y0396). This product is intended for research and analytical applications. N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer. | ||||||||||||||||||||
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Similarity Score 0.89
HY-W015423R2-Methylisoindoline-1,3-dione (Standard) -
Similarity Score 0.87
HY-Y0895N-(Hydroxymethyl)phthalimide -
Similarity Score 0.82
HY-W1032872-Hydroxyisoquinoline-1,3(2H,4H)-dione -
Similarity Score 0.81
HY-W014665N-Phthaloylglycine -
Similarity Score 0.81
HY-W759458N-Phthaloylglycine-13C2,15N -
Similarity Score 0.80
HY-W1033652-(3-Chloropropyl)isoindoline-1,3-dione -
Similarity Score 0.79
HY-W0329024-Amino-N-methylphthalimide -
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References
- [1]. Wei W J, et al. Study on N‐hydroxyphthalimide as blocking agent for isocyanates. Journal of applied polymer science, 2002, 84(7): 1346-1352.
- [2]. Melone L, et al. N-Hydroxyphthalimide catalysts as bioactive pro-oxidants. RSC Advances, 2016, 6(26): 21749-21755.
- [3]. Wang M, et al. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. J Exp Clin Cancer Res. 2016 Mar 3;35:41. [Content Brief]
