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  3. Drug Derivative
  4. 4-Amino-N-methylphthalimide

4-Amino-N-methylphthalimide (Compound 13) is an angiogenesis regulator and Thalidomide (HY-14658) derivative. 4-Amino-N-methylphthalimide exerts a bidirectional regulatory (inhibitory or promotive) effect on the proliferation of vascular endothelial cells. 4-Amino-N-methylphthalimide is applicable to the research of coronary heart disease.

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4-Amino-N-methylphthalimide

4-Amino-N-methylphthalimide Chemical Structure

CAS No. : 2307-00-8

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Based on 1 publication(s) in Google Scholar

4-Amino-N-methylphthalimide Related Antibodies

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Description

4-Amino-N-methylphthalimide (Compound 13) is an angiogenesis regulator and Thalidomide (HY-14658) derivative. 4-Amino-N-methylphthalimide exerts a bidirectional regulatory (inhibitory or promotive) effect on the proliferation of vascular endothelial cells. 4-Amino-N-methylphthalimide is applicable to the research of coronary heart disease[1].

In Vitro

4-Amino-N-methylphthalimide (38.5-385 μM; 20 h) modulates HUVEC proliferation, with a 31.32% increase at 192.5 μM and a 17.61% inhibition at 385 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Amino-N-methylphthalimide Related Antibodies

Cell Proliferation Assay[1]

Cell Line: human umbilical vein endothelial cells
Concentration: 38.5-385 μM
Incubation Time: 20 h
Result: Caused 17.61% inhibition of endothelial cell proliferation relative to 10% serum control at 385 μM.
Caused 4.39% inhibition at 289 μM.
Induced 31.32% increase in proliferation at 192.5 μM.
Caused 2.36% inhibition at 96 μM.
Induced 6.72% increase in proliferation at 38.5 μM.
Molecular Weight

176.18

Formula

C9H8N2O2
CAS No.
Appearance

Solid

SMILES

O=C1C2=CC=C(N)C=C2C(=O)N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

RT, protect from light

In solvent -80°C 1 year
-20°C 6 months
Purity & Documentation
References
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4-Amino-N-methylphthalimide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Amino-N-methylphthalimide2307-00-8Drug DerivativeDrug derivativephthalimide derivativehuman umbilical vein endothelial cellhuman vascular endothelial cellcoronary heart diseaseInhibitorinhibitorinhibit

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