1. Apoptosis
  2. Bcl-2 Family
  3. Bcl-2/Bcl-xl inhibitor 1

Bcl-2/Bcl-xl inhibitor 1 

Cat. No.: HY-129179
Handling Instructions

Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.

For research use only. We do not sell to patients.

Bcl-2/Bcl-xl inhibitor 1 Chemical Structure

Bcl-2/Bcl-xl inhibitor 1 Chemical Structure

CAS No. : 2180923-05-9

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Description

Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].

IC50 & Target

Bcl-2

2 nM (IC50)

Bcl-xL

5.9 nM (IC50)

In Vitro

Bcl-2/Bcl-xl inhibitor 1 (compound 6) exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells[1].

Molecular Weight

882.42

Formula

C₄₅H₄₈ClN₇O₈S

CAS No.

2180923-05-9

SMILES

O=C(NS(=O)(C1=CC=C(NC[[email protected]@H]2OCCOC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC(CC5)=C(C6=CC=C(Cl)C=C6)CC75CCC7)CC4)C=C3OC8=CN=C(NC=C9)C9=C8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bcl-2/Bcl-xl inhibitor 1Bcl-2 FamilyInhibitorinhibitorinhibit

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Bcl-2/Bcl-xl inhibitor 1
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