1. Apoptosis
  2. Bcl-2 Family
  3. Sabutoclax

Sabutoclax (Synonyms: BI-97C1)

Cat. No.: HY-15191
Handling Instructions

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

For research use only. We do not sell to patients.

Sabutoclax Chemical Structure

Sabutoclax Chemical Structure

CAS No. : 1228108-65-3

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Description

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

IC50 & Target[1]

Bcl-xL

0.31 μM (IC50)

BCL2

0.32 μM (IC50)

Mcl-1

0.2 μM (IC50)

Bfl-1

0.62 μM (IC50)

Molecular Weight

700.78

Formula

C₄₂H₄₀N₂O₈

CAS No.

1228108-65-3

SMILES

O=C(C1=C(O)C(O)=CC2=C(O)C(C3=C(C)C=C4C(C(NCC(C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NCC(C6=CC=CC=C6)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

Methanol : 75 mg/mL (107.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4270 mL 7.1349 mL 14.2698 mL
5 mM 0.2854 mL 1.4270 mL 2.8540 mL
10 mM 0.1427 mL 0.7135 mL 1.4270 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

SabutoclaxBI-97C1Bcl-2 FamilyInhibitorinhibitorinhibit

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