1. Apoptosis
  2. Bcl-2 Family
  3. BAI1

BAI1 

Cat. No.: HY-103269 Purity: 99.72%
Handling Instructions

BAI1 est un inhibiteur de l'activation de BAX qui est sélectif et allostérique. BAI1 démontre l'inhibition de la perméabilisation membranaire médiée par BAX induite par tBID (HY-100464) avec une IC50 de 3,3 μΜ.

BAI1 is a selective and allosteric inhibitor of BAX, an apoptosis regulator. BAI1 directly binds to BAX and allosterically inhibits BAX activation. BAI1 has the potential for the research of diseases mediated by BAX-dependent cell death.

For research use only. We do not sell to patients.

BAI1 Chemical Structure

BAI1 Chemical Structure

CAS No. : 335165-68-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 560 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

BAI1 is a selective and allosteric inhibitor of BAX, an apoptosis regulator. BAI1 directly binds to BAX and allosterically inhibits BAX activation. BAI1 has the potential for the research of diseases mediated by BAX-dependent cell death[1].

IC50 & Target[1]

Bax

 

In Vitro

BAI1 selectively inhibits BAX-mediated apoptotic cell death[1].
BAI1 shows inhibition of tBID (HY-100464)-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC50 of 3.3 μΜ[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Mouse MEF
Concentration: 0.3125 μM , 0.625 μM, 1 μM, 1.25 μM, 1.5 μM, 2.5 μM , 3 μM, 4 μM, 5 4 μM, 10 4 μM
Incubation Time: 8 hours
Result: Inhibited cell death in BAX-dependent manner.
Molecular Weight

467.20

Formula

C₁₉H₂₁Br₂N₃O

CAS No.

335165-68-9

SMILES

OC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 18.67 mg/mL (39.96 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1404 mL 10.7021 mL 21.4041 mL
5 mM 0.4281 mL 2.1404 mL 4.2808 mL
10 mM 0.2140 mL 1.0702 mL 2.1404 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.87 mg/mL (4.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.87 mg/mL (4.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BAI1BAI 1BAI-1Bcl-2 FamilyBAXmitochondrialcelldeathpathwaycriticaleffectorInhibitorinhibitorinhibit

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BAI1
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