1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Yohimbine Hydrochloride

Yohimbine Hydrochloride 

Cat. No.: HY-N0127 Purity: 99.85%
Handling Instructions

Yohimbine Hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.

For research use only. We do not sell to patients.

Yohimbine Hydrochloride Chemical Structure

Yohimbine Hydrochloride Chemical Structure

CAS No. : 65-19-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Other Forms of Yohimbine Hydrochloride:

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Description

Yohimbine Hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.

In Vivo

Yohimbine Hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1h before the stress session daily for 14 consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in cold water significantly decreased sexual arousal and motivation as indicated by increased latencies and intervals. Decreased copulatory activity was confirmed by decreased testosterone, luteinizing hormone (LH) and follicle-stimulating-hormone (FSH) levels as well as decreased cholesterol content in rat testes. Treatment with yohimbine significantly increased the sexual arousal and potency and corrected the effects induced by stress on the mating behavior of male rats[1].

Clinical Trial
Molecular Weight

390.90

Formula

C₂₁H₂₇ClN₂O₃

CAS No.

65-19-0

SMILES

[H][[email protected]]12C(NC3=C4C=CC=C3)=C4CCN1C[[email protected]@]5(CC[[email protected]](O)[[email protected]](C(OC)=O)[[email protected]]5(C2)[H])[H].[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (85.26 mM; Need ultrasonic)

H2O : 4 mg/mL (10.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5582 mL 12.7910 mL 25.5820 mL
5 mM 0.5116 mL 2.5582 mL 5.1164 mL
10 mM 0.2558 mL 1.2791 mL 2.5582 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Yohimbine Hydrochloride
Cat. No.:
HY-N0127
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