1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
    5-HT Receptor
  3. BMY 7378

BMY 7378 

Cat. No.: HY-100554
Handling Instructions

BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist.

For research use only. We do not sell to patients.

BMY 7378 Chemical Structure

BMY 7378 Chemical Structure

CAS No. : 21102-95-4

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Description

BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2].

IC50 & Target[1]

rat α1A-adrenergic receptor

800 nM (Ki)

hamster alpha1B-adrenergic receptor

600 nM (Ki)

rat alpha1D-adrenergic receptor

2 nM (Ki)

5-HT1A Receptor

 

In Vitro

BMY 7378 is selective for the alpha 1D-adrenoceptor subtype (pKi: hamster alpha 1b-adrenoceptor 6.2, human alpha 1b-adrenoceptor 7.2; bovine alpha 1c-adrenoceptor 6.1, human alpha 1c-adrenoceptor 6.6; rat alpha 1d-adrenoceptor 8.2, human alpha 1d-adrenoceptor 9.4) and has high affinity (pA2, 8.9) for rat aorta alpha 1-adrenoceptor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

458.42

Formula

C22H33Cl2N3O3

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BMY 7378
Cat. No.:
HY-100554
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