Rauwolscine  (Synonyms: α-Yohimbine; Corynanthidine; Isoyohimbine)

Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis^[1].

Rauwolscine (0.5 mg/kg, daily) reduces tumor growth by enhancing apoptosis and reducing cell proliferation in Balb/c female virgin mice^[1].
Rauwolscine (i.v., 2.24 mg/kg) can significantly release lick-shock conflict responding in rats similar to the α agonist clonidine (0.022 mg/kg) and the benzodiazepine diazepam (0.5 mg/kg) ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

354.44

C₂₁H₂₆N₂O₃

131-03-3

Solid

Light yellow to brown

[H][C@@]12[C@](CC[C@@H]([C@H]2C(OC)=O)O)(CN(CCC3=C4NC5=CC=CC=C53)[C@]4(C1)[H])[H]

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155(4):494-504.  [Content Brief]

  [2]. S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54(10):PL179-84.  [Content Brief]