1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Rauwolscine hydrochloride

Rauwolscine hydrochloride (Synonyms: α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride)

Cat. No.: HY-12710A Purity: 99.95%
Handling Instructions

Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.

For research use only. We do not sell to patients.

Rauwolscine hydrochloride Chemical Structure

Rauwolscine hydrochloride Chemical Structure

CAS No. : 6211-32-1

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10 mM * 1 mL in DMSO USD 66 In-stock
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Based on 1 publication(s) in Google Scholar

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Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.

IC50 & Target

Ki: 12 nM (α2 adrenergic receptor)[1]

In Vitro

[3H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes[1]. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors[2]. When using [3H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3 nM, Ki rat=35.8 nM)[3]. Saturation studies shows that the affinity of [3H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) [4].

Molecular Weight







[H]Cl.[H][[email protected]]12C(NC3=C4C=CC=C3)=C4CCN1C[[email protected]@]5([H])CC[[email protected]](O)[[email protected]@H](C(OC)=O)[[email protected]]5(C2)[H]


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (15.35 mM; Need ultrasonic)

H2O : 5 mg/mL (12.79 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5582 mL 12.7910 mL 25.5820 mL
5 mM 0.5116 mL 2.5582 mL 5.1164 mL
10 mM 0.2558 mL 1.2791 mL 2.5582 mL
*Please refer to the solubility information to select the appropriate solvent.
Kinase Assay

Fresh bovine frontal cortex is incubated in triplicate with [3H]Rauwolscine (82 Ci/mM, diluted). Incubation is terminated by filtration under reduced pressure over filters, which are then rinsed with ice cold Tris-HCl buffer, dried overnight and added to disposable glass minivials containing 3.0 mL of a 95% Econofluor/5% Protosol solution. Samples are counted by liquid scintillation spectrometry with an efficiency of 32%. (-)- [3H]Epinephrine binding to bovine cortex membranes is conducted at 25°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 99.95%

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Rauwolscineα-YohimbineCorynanthidineIsoyohimbineAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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