1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. CL 316243

CL 316243 

Cat. No.: HY-116771A Purity: >98.0%
Handling Instructions

CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors.CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.

For research use only. We do not sell to patients.

CL 316243 Chemical Structure

CL 316243 Chemical Structure

CAS No. : 138908-40-4

Size Price Stock Quantity
5 mg USD 320 In-stock
Estimated Time of Arrival: December 31
10 mg USD 530 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors[1].CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate[2]. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence[3].

IC50 & Target

EC50: 3 nM (β3-adrenoceptor)[1]

In Vitro

CL 316243 displays binding affinities with IC50 values of 0.6 μM and 1 μM for rat heart and rat soleus muscle respectively[1].
CL 316243 inhibits spontaneously contracting, isolated rat detrusor strips in a concentration dependent manner with a mean concentration inhibiting 50% of maximal response of 2.65 nM[3].

In Vivo

CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 weeks) elevates the mRNA and protein expression levels of UCP1 in BAT, irrespective of diet[2].

Animal Model: Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks[2]
Dosage: 0.1 mg/kg/day
Administration: once a day; 1 weeks
Result: Exhibited a premium effect of obesity in mice.
Molecular Weight

465.79

Formula

C₂₀H₁₈ClNNa₂O₇

CAS No.

138908-40-4

SMILES

O=C(C1(C(O[Na])=O)OC2=CC=C(C[[email protected]](NC[[email protected]@H](C3=CC=CC(Cl)=C3)O)C)C=C2O1)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (134.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1469 mL 10.7345 mL 21.4689 mL
5 mM 0.4294 mL 2.1469 mL 4.2938 mL
10 mM 0.2147 mL 1.0734 mL 2.1469 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

CL 316243CL316243CL-316243Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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CL 316243
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HY-116771A
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