2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. RESA peptide

RESA peptide is a substrate peptide of β-adrenergic receptor kinase (βARK). RESA peptide serves as a substrate for βARK-mediated phosphorylation, and its N-terminal acidic residues enhance phosphorylation efficiency and substrate binding capacity.

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RESA peptide

RESA peptide Chemical Structure

CAS No. : 133699-13-5

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Based on 1 publication(s) in Google Scholar

RESA peptide Related Antibodies

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Description

RESA peptide is a substrate peptide of β-adrenergic receptor kinase (βARK). RESA peptide serves as a substrate for βARK-mediated phosphorylation, and its N-terminal acidic residues enhance phosphorylation efficiency and substrate binding capacity[1].

In Vitro

The RESA peptide (RRREEEEESAAA) (0.05-7 mM; 60 min) acts as a substrate for purified βARK1 with a Vmax/Km ratio of 39, which is 240-fold higher than the basic peptide RRRASAAASAA and ~4000-fold lower than activated rhodopsin[1].
The RESA peptide (RRREEEEESAAA) (0.05-3 mM; 60 min) had its βARK1-mediated phosphorylation slightly inhibited by light-activated rhodopsin (Rho'), reducing the Vmax/Km ratio to 0.6-fold of the value measured in the absence of Rho'[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RESA peptide Related Antibodies
Molecular Weight

1432.45

Formula

C55H93N21O24
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Arg-Arg-Glu-Glu-Glu-Glu-Glu-Ser-Ala-Ala-Ala
Sequence Shortening

RRREEEEESAAA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (69.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6981 mL 3.4905 mL 6.9810 mL
5 mM 0.1396 mL 0.6981 mL 1.3962 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6981 mL 3.4905 mL 6.9810 mL 17.4526 mL
5 mM 0.1396 mL 0.6981 mL 1.3962 mL 3.4905 mL
10 mM 0.0698 mL 0.3491 mL 0.6981 mL 1.7453 mL
15 mM 0.0465 mL 0.2327 mL 0.4654 mL 1.1635 mL
20 mM 0.0349 mL 0.1745 mL 0.3491 mL 0.8726 mL
25 mM 0.0279 mL 0.1396 mL 0.2792 mL 0.6981 mL
30 mM 0.0233 mL 0.1164 mL 0.2327 mL 0.5818 mL
40 mM 0.0175 mL 0.0873 mL 0.1745 mL 0.4363 mL
50 mM 0.0140 mL 0.0698 mL 0.1396 mL 0.3491 mL
60 mM 0.0116 mL 0.0582 mL 0.1164 mL 0.2909 mL
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RESA peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RESA peptide133699-13-5Adrenergic ReceptorBeta Receptorβ-adrenergic receptor kinaselight-activated truncated rhodopsinβARKlight-activated intact rhodopsin329G-Rho'rhodopsinβARK1Rho'Inhibitorinhibitorinhibit

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