39226-94-3
Chemical Structure
LY 78335
Synonym(s): DCMB
- CAS No.: 39226-94-3
- Formula:C8H9Cl2N
- Molecular Weight:190.07
IUPAC Name: 1-(2,3-dichlorophenyl)ethan-1-amine
InChIKey: CZJMQTZQSNUDNV-UHFFFAOYSA-N
SMILES: ClC1=CC=CC(=C1Cl)C(N)C
Biological Activity: LY 78335 (DCMB) is a brain-penetrant phenylethanolamine-N-methyltransferase (PNMT) inhibitor with a Ki of 0.09 μM. LY 78335 acts as an α₂-adrenoceptor inhibitor with an IC50 of 10 μM. LY 78335 increases spontaneous locomotor activity in rats. LY 78335 increases extracellular concentration of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rat hypothalamus. LY 78335 prevents growth hormone (GH) secretion in rats. LY 78335 can be used for the research of depression[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY 78335 | 99.19% | LY 78335 (DCMB) is a brain-penetrant phenylethanolamine-N-methyltransferase (PNMT) inhibitor with a Ki of 0.09 μM. LY 78335 acts as an α₂-adrenoceptor inhibitor with an IC50 of 10 μM. LY 78335 increases spontaneous locomotor activity in rats. LY 78335 increases extracellular concentration of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rat hypothalamus. LY 78335 prevents growth hormone (GH) secretion in rats. LY 78335 can be used for the research of depression. | ||||||||||||||||||||
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