2. Apoptosis NF-κB
  3. TNF Receptor NF-κB Apoptosis
  4. TNF-α (31-45), human

TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.

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CAS No. : 144796-71-4

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Based on 11 publication(s) in Google Scholar

Other Forms of TNF-α (31-45), human:

TNF-α (31-45), human Related Antibodies

Top Publications Citing Use of Products

    TNF-α (31-45), human purchased from MedChemExpress. Usage Cited in: PLoS One. 2025 Apr 16;20(4):e0318311.  [Abstract]

    TNF-α (31-45), human (100 ng/mL; 24 h). In vitro experimental validation was performed using Western blot.

    TNF-α (31-45), human purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Dec 15:961:176193.  [Abstract]

    TNF-α(31-45), human (10 ng/mL; 24 h). The LDH level of supernatant from TNF-α-stimulated hepatocytes.

    TNF-α (31-45), human purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Dec 15:961:176193.  [Abstract]

    TNF-α (31-45), human (10 ng/mL; 24 h). Immunoblotting of cleaved caspases 8 and 3 in TNF-α-stimulated hepatocytes. Blots were normalized to endogenous β-actin.

    TNF-α (31-45), human purchased from MedChemExpress. Usage Cited in: Biomedicines. 2023 Dec 15;11(12):3314.

    TNF-α (31-45), human (0.5-2 μg/L; 48 h). Effects of dose-elevated TNF-α on the protein levels of MATE1 and OCT2 in HK-2 cells.

    TNF-α (31-45), human purchased from MedChemExpress. Usage Cited in: Cytotechnology. 2021 Oct;73(5):727-743.

    TNF-α (31-45), human (0.5 ng/mL). The expression of miR-200b-3p in each group was detected by qRT-PCR.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3].

    IC50 & Target[1][2]

    NF-κB

     

    In Vitro

    TNF-α (31-45), human (5 μM; for 1 h) promotes cisplatin resistance by the activation of the NF-kB pathway. TNF-α (31-45), human does not alter RPS3 expression levels[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    TNF-α (31-45), human Related Antibodies
    Molecular Weight

    1667.87

    Formula

    C69H122N26O22
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Arg-Arg-Ala-Asn-Ala-Leu-Leu-Ala-Asn-Gly-Val-Glu-Leu-Arg-Asp
    Sequence Shortening

    RRANALLANGVELRD
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light, under nitrogen

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (29.98 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.5996 mL 2.9978 mL 5.9957 mL
    5 mM 0.1199 mL 0.5996 mL 1.1991 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.99%

    SDS (252 KB)

    COA (248 KB) RP-HPLC (251 KB) MS (70 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.5996 mL 2.9978 mL 5.9957 mL 14.9892 mL
    5 mM 0.1199 mL 0.5996 mL 1.1991 mL 2.9978 mL
    10 mM 0.0600 mL 0.2998 mL 0.5996 mL 1.4989 mL
    15 mM 0.0400 mL 0.1999 mL 0.3997 mL 0.9993 mL
    20 mM 0.0300 mL 0.1499 mL 0.2998 mL 0.7495 mL
    25 mM 0.0240 mL 0.1199 mL 0.2398 mL 0.5996 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    TNF-α (31-45), human Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    TNF-α (31-45), human144796-71-4TNF ReceptorNF-κBApoptosisTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBproinflammatory cytokinenecrosisinvasionmetastasisInhibitorinhibitorinhibit

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