TNF-α (31-45), human TFA

Name: TNF-α (31-45), human TFA
Brand: MedChemExpress
SKU: HY-P1860A
Rating: 5.0 (11 reviews)

Cat. No.: HY-P1860A Purity: 99.40%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of TNF-α (31-45), human TFA:

TNF-α (31-45), human In-stock

11 Publications Citing Use of MCE TNF-α (31-45), human TFA

Bio/Physico-chemical Assay

RT-PCR

: TNF-α (31-45), human TFA purchased from MedChemExpress. Usage Cited in: PLoS One. 2025 Apr 16;20(4):e0318311. [Abstract]; TNF-α (31-45), human (100 ng/mL; 24 h). In vitro experimental validation was performed using Western blot.

: TNF-α (31-45), human TFA purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Dec 15:961:176193. [Abstract]; TNF-α(31-45), human (10 ng/mL; 24 h). The LDH level of supernatant from TNF-α-stimulated hepatocytes.

: TNF-α (31-45), human TFA purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Dec 15:961:176193. [Abstract]; TNF-α (31-45), human (10 ng/mL; 24 h). Immunoblotting of cleaved caspases 8 and 3 in TNF-α-stimulated hepatocytes. Blots were normalized to endogenous β-actin.

: TNF-α (31-45), human TFA purchased from MedChemExpress. Usage Cited in: Biomedicines. 2023 Dec 15;11(12):3314.; TNF-α (31-45), human (0.5-2 μg/L; 48 h). Effects of dose-elevated TNF-α on the protein levels of MATE1 and OCT2 in HK-2 cells.

: TNF-α (31-45), human TFA purchased from MedChemExpress. Usage Cited in: Cytotechnology. 2021 Oct;73(5):727-743.; TNF-α (31-45), human (0.5 ng/mL). The expression of miR-200b-3p in each group was detected by qRT-PCR.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]

NF-κB

In Vitro

TNF-α (31-45), human (5 μM; for 1 h) TFA promotes cisplatin resistance by the activation of the NF-kB pathway. TNF-α (31-45), human does not alter RPS3 expression levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1667.87 (free acid)

Formula

C₆₉H₁₂₂N₂₆O₂₂.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

Arg-Arg-Ala-Asn-Ala-Leu-Leu-Ala-Asn-Gly-Val-Glu-Leu-Arg-Asp

Sequence Shortening

RRANALLANGVELRD

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.40%

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Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (368 KB) MS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000 Aug 1;50(3):184-95. [Content Brief]

[2]. Xi Rui, et al. RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma. Front Oncol. 2022 Jun 30:12:804439. [Content Brief]

[3]. Jang DI, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021 Mar 8;22(5):2719. [Content Brief]