1. Recombinant Proteins
  2. IL-1 beta Protein, Human

IL-1 beta Protein, Human

Cat. No.: HY-P7028
Handling Instructions

IL-1 beta Protein, Human is a polypeptidic cytokine that play a key role in inflammation and immunologic reactions.

For research use only. We do not sell to patients.

Protein Expression Service

Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $190 In-stock
Estimated Time of Arrival: December 31
50 μg $440 In-stock
Estimated Time of Arrival: December 31
100 μg $770 In-stock
Estimated Time of Arrival: December 31
250 μg   Get quote  

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  • Technical Parameters

  • Properties

  • Documentation

rHuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B



E. coli


P01584 (A117-S269)

Gene ID


Molecular Weight

Approximately 17.3 kDa

AA Sequence


Biological Activity
The ED50 is <1.0 pg/mL as measured by murine D10S cells, corresponding to a specific activity of 1.0 × 109 units/mg.

Lyophilized powder.


Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<0.2 EU/μg, determined by LAL method.


It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.


Room temperature in continental US; may vary elsewhere.


Recombinant Human Interleukin-1 beta (IL-1β) is a non-glycosylated polypeptide chain containing 153 amino acids with a molecular mass of 17000 Daltons. The purified human monocyte derived IL-1 (mIL-1), a mixture of the two IL-1 forms but predominantly consisting of IL-1 beta, modulates eosinophil oxidative metabolism and enzyme secretion. Although the two major species of IL-1 (IL-1 alpha and IL-1 beta) have identical specific activities on T cells, the selective effects of human recombinant IL-1 (hrIL-1) alpha and hrIL-1 beta are reported on eosinophil function. Recombinant Human Interleukin-1 beta (hrIL-1 beta) causes a significant increase in arylsulfatase secretion (235.4±29% of resting secretion, P≤0.01) and beta-glucuronidase secretion (135.8±9.6% of resting secretion, P≤0.02) similar to mIL-1, Recombinant Human Interleukin-1 alpha (hrIL-1 alpha) has no effect on enzyme secretion. A mixture of hrIL-1 alpha and hrIL-1 beta reproduces the ability of mIL-1 to inhibit the oxidative response to suboptimal doses of phorbol myristate acetate (PMA). When eosinophils are separated into subpopulations by density gradients, eosinophil responses to IL-1 differ among the populations[1]. Members of the IL-1 family such as IL-1α and IL-1β are pro-inflammatory cytokines. Increased IL-1α and IL-1β levels have been detected separately in cigarette smoke (CS)-treated animals and inhibition of the respective signaling pathways result in anti-inflammatory activity[2].

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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IL-1 beta Protein, Human
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