2205034-18-8
Chemical Structure
IL-17A antagonist 1
- CAS No.: 2205034-18-8
- Formula:C33H41FN6O4
- Molecular Weight:604.71
IUPAC Name: (S)-N-(1-((4-(2-(2-(1-(2-(dimethylamino)-2-oxoethyl)cyclopentyl)acetamido)ethyl)phenyl)amino)-3-(2-fluorophenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide
InChIKey: VWRXSIAIHJZTCV-MHZLTWQESA-N
SMILES: O=C(N(C)C)CC1(CC(NCCC2=CC=C(NC([C@H](CC3=CC=CC=C3F)NC(C4=CC=NN4C)=O)=O)C=C2)=O)CCCC1
Biological Activity: IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC50 of 1.14 μM and a Kd of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
IL-17A antagonist 1 | 99.74% | IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC50 of 1.14 μM and a Kd of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
IL-17A antagonist 1 (Standard) | ≥98% | IL-17A antagonist 1 (Standard) is the analytical standard of IL-17A antagonist 1 (HY-101913). This product is intended for research and analytical applications. IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC50 of 1.14 μM and a Kd of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
