Dextran
Based on 2 publication(s) in Google Scholar
Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 9004-54-0
- Molecular Weight:40000.00
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dextran
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Biological Activity
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Dextran can be used in animal modeling to create paw edema models. Injection of dextran at doses of either 7.9 mg/kg or 300 mg/kg results in edema of equal intensity in the limbs[1][2].
Administration: 1% dextran (20 μL/paw)• intraplantar injection in the right hind paw• a single dose for 1, 2, 3 and 4 h[1].
Rat: Albino of of the Sprague Dawleq strain• weighing 110-130 g• seven-week-old[2].
Administration: 0.5 mL/100 g • tail vein injection• a single dose[2].
Histological analysis: Mast-cell disruption (histamine and serotonili release), vasodilatation, hypothermia, hypotension, helnoconcentration and edema occurred with the high doses of Dextran. Since minute doses of dextran induced only vasodilatation and edema formation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9004-54-0
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Appearance Solid
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Molecular Weight 40000.00
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Color White to off-white
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SMILES
[Dextran]
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Synonyms
Dextran 40
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Carbohydr Polym
Unraveling role of the glucan-binding domain in mutansucrase-mediated glucan synthesis and biofilm-related properties. [Abstract]2025 Dec 1:369:124270. PMID: 40973254 -
Solvent & Solubility
H2O : 100 mg/mL (2.50 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Santos ES, et al. Anti-inflammatory activity of herb products from Licania rigida Benth. Complement Ther Med. 2019 Aug;45:254-261. [Content Brief]
[2]. GOEZSY B, et al. INVESTIGATIONS INTO THE MECHANISM OF DEXTRANINDUCED EDEMA IN RATS. Can J Biochem Physiol. 1963 Sep;41:1855-63. [Content Brief]
[3]. REDEI A. Investigations on the mechanism of dextran induced oedema in rats. Med Exp Int J Exp Med. 1962;6:73-8. [Content Brief]
[4]. Bark BP, et al. Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig. Acta Anaesthesiol Scand. 2014 Jan;58(1):44-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 0.0250 mL | 0.1250 mL | 0.2500 mL | 0.6250 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dextran Related Classifications
HY-112624 Related Classifications
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