Dextran T20 (MW 20,000)
Based on 1 Customer Validation
Dextran T20 (Dextran 20; Dextran D20) (MW 20,000) is a dehydrated glucose polymer with an average molecular weight of 20,000. Dextran T20 (MW 20,000) has excellent biodegradability and good biocompatibility, and can be used as a gene delivery vector, an immune adjuvant carrier, and a hemoglobin stabilizer.
For research use only. We do not sell to patients.
- CAS No.: 9004-54-0
- Formula: (C6H10O5)n
- Molecular Weight:16000-24000
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Dextran T20 (MW 20,000) is covalently bound to bovine hemoglobin, forming a stable dextransome-hemoglobin complex (dex20-bHb). dex20-bHb significantly reduces the self-oxidation rate of hemoglobin by enhancing the tetramer stability and oxygen affinity of hemoglobin1.
Dextran T20 (MW 20,000) can be used to construct cytosine-phosphate-guanine (CpG)-right glycolic acid conjugates. These conjugates can significantly enhance the uptake by antigen-presenting cells and trigger a strong immune response, but their relatively small size may not be sufficient to provide strong resistance to nucleases[2].
Dextran T20 (MW 20,000) is covalently bound to a cationic peptide R5H5 to form a right-handed dextran-peptide hybrid (Dex-R5H5), which is used for the safe and effective delivery of genes (plasmid DNA)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9004-54-0
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Appearance Solid
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Molecular Weight 16000-24000
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Formula (C6H10O5)n
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Color White to off-white
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SMILES
[Dextran T20 (MW 20,000)]
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Synonyms
Dextran 20; Dextran D20; Dextran T20(MW 16000-24000)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang J, et al. Conjugation with 20 kDa dextran decreases the autoxidation rate of bovine hemoglobin. Artif Cells Nanomed Biotechnol. 2018 Nov;46(7):1436-1443. [Content Brief]
[2]. Nguyen HV, et al. Effect of carrier molecular weight on physicochemical properties and the in vitro immune-stimulatory activity of the CpG-dextran conjugates. Int J Pharm. 2022 Nov 5;627:122236. [Content Brief]
[3]. Tang Q, et al. Dextran-peptide hybrid for efficient gene delivery. Langmuir. 2014 May 13;30(18):5202-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dextran T20 (MW 20,000) Related Classifications
HY-112624U Related Classifications
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