Dextran sulfate sodium salt (MW>500000)
Based on 1 Customer Validation
Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. Dextran sulfate sodium salt has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate sodium salt can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent.
For research use only. We do not sell to patients.
- Assay : 98.51%
- CAS No.: 9011-18-1
- Molecular Weight:>500000
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-116282C
Dextran sulfate sodium salt (MW 35000-45000) -
HY-116282
Dextran sulfate sodium salt (MW 5000) -
HY-116282D
Dextran sulfate sodium salt (MW 450000-550000) -
HY-116282A
Dextran sulfate sodium salt (MW 4500-5500) -
HY-116282M
Dextran sulfate, low sulfate (MW 40000) -
HY-116282B
Dextran sulfate sodium salt (MW 16000-24000) -
HY-116282H
Dextran sulfate sodium salt (MW 9000-20000) -
HY-116282J
Dextran sulfate, low sulfate (MW 5000) -
HY-116282P
Dextran sulfate, high sulfate (MW 5000) -
HY-116282W
Dextran sulfate sodium salt (MW 6500-10000) -
HY-125861
Methyl cellulose(Viscosity:100000mPa.s)
Biological Activity
Description
In Vitro
Dextran sulfate sodium salt (MW>500000) (0-1000 μg/mL; 48 h) potently inhibits HSV-1, HCoV-229E, LV-St and LV-VSV infection without obvious cytotoxicity in Vero, Huh-7 and ACE2+HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero cells
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Concentration:0 μg/mL, 10 μg/mL, 50 μg/mL, 100 μg/mL, 500 μg/mL, 1000 μg/mL
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Incubation Time:48 h
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Result:Maintained cell viability above 80% at all concentrations.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tg-K18hACE2 transgenic mice (8 weeks old) intranasally infected with SARS‑CoV‑2 (Navarra‑2473 strain)[1]
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Dosage:5 mg/mL
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Administration:Nebulization inhalation, once daily, 30 min per time, on days 4, 5, 6 and 7 post‑infection
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Result:Significantly prevented body weight loss, reduced clinical morbidity, improved survival rate.
Decreased lung viral RNA copies, mitigated histopathological lung damage and lowered SARS‑CoV‑2 nucleocapsid protein expression in lung tissues.
Chemical Information
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CAS No. 9011-18-1
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Appearance Solid
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Molecular Weight >500000
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Color White to off-white
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SMILES
[Dextran sulfate sodium salt]
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Synonyms
DSS (MW>500000); DXS (MW>500000)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Andreu S, et al. Dextran sulfate from Leuconostoc mesenteroides B512F exerts potent antiviral activity against SARS-CoV-2 in vitro and in vivo. Front Microbiol. 2023 May 3;14:1185504. [Content Brief]
[2]. Sahagun G, et al. Permeability of neutral vs. anionic dextrans in cultured brain microvascular endothelium. Am J Physiol. 1990 Jul;259(1 Pt 2):H162-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dextran sulfate sodium salt (MW>500000) Related Classifications
HY-116282I Related Classifications
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