2. Anti-infection
  3. HSV SARS-CoV
  4. Dextran sulfate sodium salt (MW>500000)

Dextran sulfate sodium salt (MW>500000)  (Synonyms: DSS (MW>500000); DXS (MW>500000))

Cat. No.: HY-116282I Assay: 98.51%
COA
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Handling Instructions Technical Support

Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. Dextran sulfate sodium salt has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate sodium salt can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent.

For research use only. We do not sell to patients.

Dextran sulfate sodium salt (MW>500000)

Dextran sulfate sodium salt (MW>500000) Chemical Structure

CAS No. : 9011-18-1

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Dextran sulfate sodium salt (MW>500000) Related Antibodies

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Description

Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. Dextran sulfate sodium salt has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate sodium salt can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent[1].

In Vitro

Dextran sulfate sodium salt (MW>500000) (0-1000 μg/mL; 48 h) potently inhibits HSV-1, HCoV-229E, LV-St and LV-VSV infection without obvious cytotoxicity in Vero, Huh-7 and ACE2+HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran sulfate sodium salt (MW>500000) Related Antibodies

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: 0 μg/mL, 10 μg/mL, 50 μg/mL, 100 μg/mL, 500 μg/mL, 1000 μg/mL
Incubation Time: 48 h
Result: Maintained cell viability above 80% at all concentrations.
In Vivo

Dextran sulfate sodium salt (MW>500000) (50 mg/mL; nebulization inhalation; days 4-7 post-infection) significantly reduces pulmonary SARS-CoV-2 load, alleviates lung injury and improves the survival rate in Tg-K18hACE2 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg-K18hACE2 transgenic mice (8 weeks old) intranasally infected with SARS‑CoV‑2 (Navarra‑2473 strain)[1]
Dosage: 5 mg/mL
Administration: Nebulization inhalation, once daily, 30 min per time, on days 4, 5, 6 and 7 post‑infection
Result: Significantly prevented body weight loss, reduced clinical morbidity, improved survival rate.
Decreased lung viral RNA copies, mitigated histopathological lung damage and lowered SARS‑CoV‑2 nucleocapsid protein expression in lung tissues.
Molecular Weight

>500000

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran sulfate sodium salt]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.51%

SDS (251 KB)

COA (241 KB)

Handling Instructions (2659 KB)
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Dextran sulfate sodium salt (MW>500000) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dextran sulfate sodium salt (MW>500000)9011-18-1DSS (MW>500000) DXS (MW>500000)HSVSARS-CoVHerpes simplex virusSARS coronavirusInhibitorinhibitorinhibit

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