2. Anti-infection
  3. HSV SARS-CoV
  4. Dextran sulfate sodium salt (MW>500000)

Dextran sulfate sodium salt (MW>500000)  (Synonyms: DSS (MW>500000); DXS (MW>500000))

Cat. No.: HY-116282I Assay: 98.51%
COA
SDS
Handling Instructions Technical Support

Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. Dextran sulfate sodium salt has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate sodium salt can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent.

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Dextran sulfate sodium salt (MW>500000)

Dextran sulfate sodium salt (MW>500000) 화학구조

CAS No. : 9011-18-1

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
500 mg 해외재고보유
1 g 해외재고보유
5 g   견적 받기  
10 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Dextran sulfate sodium salt (MW>500000) Related Antibodies

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  • 순도&문서

  • References

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제품 설명

Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. Dextran sulfate sodium salt has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate sodium salt can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent[1].

In Vitro

Dextran sulfate sodium salt (MW>500000) (0-1000 μg/mL; 48 h) potently inhibits HSV-1, HCoV-229E, LV-St and LV-VSV infection without obvious cytotoxicity in Vero, Huh-7 and ACE2+HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran sulfate sodium salt (MW>500000) Related Antibodies

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: 0 μg/mL, 10 μg/mL, 50 μg/mL, 100 μg/mL, 500 μg/mL, 1000 μg/mL
Incubation Time: 48 h
Result: Maintained cell viability above 80% at all concentrations.
In Vivo

Dextran sulfate sodium salt (MW>500000) (50 mg/mL; nebulization inhalation; days 4-7 post-infection) significantly reduces pulmonary SARS-CoV-2 load, alleviates lung injury and improves the survival rate in Tg-K18hACE2 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg-K18hACE2 transgenic mice (8 weeks old) intranasally infected with SARS‑CoV‑2 (Navarra‑2473 strain)[1]
Dosage: 5 mg/mL
Administration: Nebulization inhalation, once daily, 30 min per time, on days 4, 5, 6 and 7 post‑infection
Result: Significantly prevented body weight loss, reduced clinical morbidity, improved survival rate.
Decreased lung viral RNA copies, mitigated histopathological lung damage and lowered SARS‑CoV‑2 nucleocapsid protein expression in lung tissues.
분자량

>500000

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran sulfate sodium salt]
선적

Room temperature in continental US; may vary elsewhere.
보관

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
용액&용해도
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 98.51%

SDS (251 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References
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Dextran sulfate sodium salt (MW>500000) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dextran sulfate sodium salt (MW>500000)9011-18-1DSS (MW>500000) DXS (MW>500000)HSVSARS-CoVHerpes simplex virusSARS coronavirusInhibitorinhibitorinhibit

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상품명:
Dextran sulfate sodium salt (MW>500000)
Cat. No.:
HY-116282I
수량:
MCE Japan Authorized Agent:

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