Dextran sulfate sodium salt (MW 6500-10000)
Based on 1 Customer Validation
Dextran sulfate sodium salt (DSS) (MW 6500-10000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 6500-10000) has antiviral activity against HIV-1 and HIV-2. Dextran sulfate sodium salt (MW 6500-10000) blocks the binding of virions to CD4⁺ T lymphocytes and inhibits syncytia formation. Dextran sulfate sodium salt (MW 6500-10000) also prevents experimental urolithiasis due to its cytoprotective actions. Moreover, because of its biocompatible and highly charged properties, Dextran sulfate sodium salt (MW 6500-10000) is a suitable choice for pharmaceutical systems.
For research use only. We do not sell to patients.
- CAS No.: 9011-18-1
- Molecular Weight:6500-10000
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-116282C
Dextran sulfate sodium salt (MW 35000-45000) -
HY-116282
Dextran sulfate sodium salt (MW 5000) -
HY-116282D
Dextran sulfate sodium salt (MW 450000-550000) -
HY-116282A
Dextran sulfate sodium salt (MW 4500-5500) -
HY-116282I
Dextran sulfate sodium salt (MW>500000) -
HY-116282M
Dextran sulfate, low sulfate (MW 40000) -
HY-116282B
Dextran sulfate sodium salt (MW 16000-24000) -
HY-116282H
Dextran sulfate sodium salt (MW 9000-20000) -
HY-116282J
Dextran sulfate, low sulfate (MW 5000) -
HY-116282P
Dextran sulfate, high sulfate (MW 5000) -
HY-125861
Methyl cellulose(Viscosity:100000mPa.s) -
HY-128868A
FITC-Dextran (MW 4000)
Biological Activity
Description
In Vitro
Antiviral activity:
Dextran sulfate sodium salt (MW 8000) (6.75 μM, 48 h) inhibits syncytia formation between CD4+ ATH8 cells and HIV-1 infected H9 cells[1].
Cytoprotective activity:
Dextran sulfate sodium salt (MW 6500-10000) (100, 500 μM, 24 h) protects mouse and human β-cells against death induced by the combination of IL-1β, TNF-α, and IFN-γ[3].
Dextran sulfate sodium salt (MW 6500-10000) (100, 500 μM, 24 h) decreases IFN-γ, TNF-α, and IL-1β signaling pathways in human islets[3].
Used as coating material:
Dextran sulfate sodium salt (MW 6500-10000) can be used to coat quantum dots to target scavenger receptors on macrophages[4].
Dextran sulfate sodium salt (MW 6500-10000) can be used to coat PEI-GLU layer (an enzyme multilayer combi-biocatalyst) to generate a more hydrophilic surface[5].
Dextran sulfate sodium salt (MW 6500-10000) can be used for formulation of Melittin/DS nanocomplex (based on strong electrostatic interactions between positively charged peptides and polyelectrolytes), which overcomes the high acute toxicity and short in vivo half-life of Melittin[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dextran sulfate sodium salt (MW 6500-10000) (10 mg/kg, i.p., for 4 weeks) prevents T1D development in prediabetic NOD mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD mice[3]
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Dosage:10 mg/kg
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Administration:i.p., for 4 weeks (8-week-old NOD mice); i.p., for 11 weeks (10-week-old prediabetic NOD female mice);
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Result:Improved glucose tolerance, and diminished β-cell death and insulitis (8-week-old NOD mice).
Lowers blood glucose and increased plasma insulin and β-cell mass (10-week-old prediabetic NOD female mice).
Reduced the expression of genes such as Il-1β, Tnf-α, Cxcl9, and Cxcl10 in pancreas (8-week-old NOD mice).
Chemical Information
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CAS No. 9011-18-1
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Appearance Solid
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Molecular Weight 6500-10000
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Color White to off-white
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SMILES
[Dextran sulfate sodium salt]
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Synonyms
DSS (MW 6500-10000); DXS (MW 6500-10000)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. 1. Mitsuya H, et al. Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells. Science. 1988 Apr 29;240(4852):646-9. [Content Brief]
[2]. 2. Tostes V, et al. Low-molecular-weight dextran sulfate prevents experimental urolithiasis in rats. Clin Chim Acta. 2004 Mar;341(1-2):147-55. [Content Brief]
[3]. 3. Lu G, et al. Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes. Diabetes. 2020 Aug;69(8):1692-1707. [Content Brief]
[4]. 4. Tu C, et al. Paramagnetic, silicon quantum dots for magnetic resonance and two-photon imaging of macrophages. J Am Chem Soc. 2010 Feb 17;132(6):2016-23. [Content Brief]
[6]. 6. Gui Z, et al. Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood glycemic control in a mouse model of type II diabetes. Int J Pharm. 2020 Mar 15;577:119071. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dextran sulfate sodium salt (MW 6500-10000) Related Classifications
HY-116282W Related Classifications
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