Dextran sulfate, high sulfate (MW 5000) 

Dextran sulfate, high sulfate (MW 5000) is a type of dextran sulfate with a high degree of sulfation. Dextran sulfate sodium can be used to induce ulcerative colitis models, and the greater the total number of sulfur atoms, the stronger the induced toxic effect. Dextran sulfate has certain antibacterial activity, and can form the ionic cross-linking core of nanoparticles together with chitosan, serving as a highly efficient dressing material to accelerate wound healing^[1][2].

Dextran sulfate sodium (5% (w/v); p.o.; ad libitum; 7 days) induces colitis in female BALB/c Cr Slc mice. Low-molecular-weight (5kD) dextran sulfate mainly causes mild, focal lesions in the cecum and proximal colon, whereas high-molecular-weight (40kD) dextran sulfate induces more severe, diffuse colitis, with lesions predominantly localized in the distal colon^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5000 (Average)

9011-18-1

[Dextran sulfate sodium salt]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kitajima S, et al. Histological analysis of murine colitis induced by dextran sulfate sodium of different molecular weights. Exp Anim. 2000;49(1):9-15.  [Content Brief]

  [2]. Darwish MM, et al. Aloe Vera coated Dextran Sulfate/Chitosan nanoparticles (Aloe Vera @ DS/CS) encapsulating Eucalyptus essential oil with antibacterial potent property. J Biomater Sci Polym Ed. 2023 Apr;34(6):810-827.
   [Content Brief]