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SB290157 trifluoroacetate

34 Cited Publications
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Based on 34 publication(s) in Google Scholar

SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM.

For research use only. We do not sell to patients.

  • Purity: 99.82%
  • CAS No.: 1140525-25-2
  • Formula: C24H29F3N4O6
  • Molecular Weight:526.51
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • SB290157 trifluoroacetate Chemical Structure
    SB290157 trifluoroacetate Chemical Structure
  • Experimental Validation Results for SB290157 trifluoroacetate
  • Experimental Validation Results for SB290157 trifluoroacetate
  • Experimental Validation Results for SB290157 trifluoroacetate
  • Experimental Validation Results for SB290157 trifluoroacetate
  • Experimental Validation Results for SB290157 trifluoroacetate
  • Experimental Validation Results for SB290157 trifluoroacetate
CAS No.: 1140525-25-2
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  • SB290157 trifluoroacetate Chemical Structure
    SB290157 trifluoroacetate Chemical Structure
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  • 1/16

    SB290157 trifluoroacetate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2484386. [Abstract]

    Customer Validation
     After pretreatment with SB290157 (C3aR inhibitor, 10 μM) for 24 hours, cells were treated with M28 (5 µg/mL) for an additional 24 hours. The cells were then washed twice with PBS to remove M28, and incubation was continued. 5 days later, macrophages were stimulated with LPS (100 ng/mL) for 24 hours. Supernatants were collected to measure NO levels.

  • 1/16

    SB290157 trifluoroacetate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2484386. [Abstract]

    Customer Validation
     After pretreatment with SB290157 (C3aR inhibitor, 10 μM) for 24 hours, cells were treated with M28 (5 µg/mL) for an additional 24 hours. The cells were then washed twice with PBS to remove M28, and incubation was continued. 5 days later, macrophages were stimulated with LPS (100 ng/mL) for 24 hours. Supernatants were collected to measure TNF-α levels.

  • 1/16

    SB290157 trifluoroacetate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2484386. [Abstract]

    Customer Validation
     After pretreatment with SB290157 (C3aR inhibitor, 10 μM) for 24 hours, cells were treated with M28 (5 µg/mL) for an additional 24 hours. The cells were then washed twice with PBS to remove M28, and incubation was continued. 5 days later, macrophages were infected with S. aureus (MOI = 5). Phagocytosis of S. aureus were assessed at 1 and 3, 6 hours post-reinfection (n = 3).

  • 1/16

    SB290157 trifluoroacetate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2484386. [Abstract]

    Customer Validation
     After pretreatment with SB290157 (C3aR inhibitor, 10 μM) for 24 hours, cells were treated with M28 (5 µg/mL) for an additional 24 hours. The cells were then washed twice with PBS to remove M28, and incubation was continued. 5 days later, macrophages were infected with S. aureus (MOI = 5). Intracellular killing of S. aureus were assessed at 1 and 3, 6 hours post-reinfection (n = 3).

  • 1/16

    SB290157 trifluoroacetate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2484386. [Abstract]

    Customer Validation
     Western blot analysis of HIF-1α protein expression in M28-trained macrophages 3 days after inhibition of CFB (Iptacopan, 10 µM) or C3aR (SB290157, 10 µM, 24 h).

  • 1/16

    SB290157 trifluoroacetate purchased from MedChemExpress. Usage Cited in: Animals (Basel). 2023 Feb 24;13(5):837. [Abstract]

    Customer Validation
     SB290157 trifluoroacetate (10 mg/kg; i.p.; single) significantly down-regulates the protein level of C3aR in mouse ileum tissues, 3 hours after injection.

  • SB290157 trifluoroacetate