1. Immunology/Inflammation
  2. Complement System
  3. Compstatin

Compstatin 

Cat. No.: HY-P1036 Purity: 98.36%
Handling Instructions

Compstatin is a 13-residue cyclic peptide, and a potent inhibitor of the complement system.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Compstatin Chemical Structure

Compstatin Chemical Structure

CAS No. : 206645-99-0

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500 μg USD 80 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
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50 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Compstatin

    Compstatin purchased from MCE. Usage Cited in: J Mater Chem B. 2019 May. 

    The transfection characterized by inverted fluorescence microscope. GFP-3T3 cells and GFP-MCF-7 cells cultured with 10% FBS were transfected with the addition of C3a or compstatin under the influence of magnetic fields or not.
    • Biological Activity

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    Description

    Compstatin is a 13-residue cyclic peptide, and a potent inhibitor of the complement system.

    In Vitro

    Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans); Compstatin inhibits only the activation of primates' complement system[1].

    In Vivo

    Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures[1]. Pig xenografts survival is significantlylonger in the Compstatin perfused group than in the control group. At rejection the biopsy samples obtained from kidneysperfused with Compstatin show less deposition of C3 and fibrin than do the control kidneys[2].

    Molecular Weight

    1550.77

    Formula

    C₆₆H₉₉N₂₃O₁₇S₂

    CAS No.

    206645-99-0

    Sequence

    Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12)

    Sequence Shortening

    ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12)

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 300 mg/mL (193.45 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6448 mL 3.2242 mL 6.4484 mL
    5 mM 0.1290 mL 0.6448 mL 1.2897 mL
    10 mM 0.0645 mL 0.3224 mL 0.6448 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Animal Administration
    [2]

    Compstatin-perfused circuit: pig xenografts are perfused with human blood containing Compstatin (final conc. 0.088 mg/mL). Control group: pig kidneys perfused with human blood and control agent. The total fluid volume, protein concentration and amount of blood are equal in both the Compstatin and control perfusion circuits, and the perfusion is performed in both circuits simultaneously with pooled blood from the same two donors.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Product Name:
    Compstatin
    Cat. No.:
    HY-P1036
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