1. Immunology/Inflammation
  2. Complement System
  3. Compstatin

Compstatin 

Cat. No.: HY-P1036 Purity: 98.34%
Handling Instructions

Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Compstatin Chemical Structure

Compstatin Chemical Structure

CAS No. : 206645-99-0

Size Price Stock Quantity
500 μg USD 80 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Compstatin:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Compstatin

    Compstatin purchased from MCE. Usage Cited in: J Mater Chem B. 2019, 7, 4207-4216.

    The transfection characterized by inverted fluorescence microscope. GFP-3T3 cells and GFP-MCF-7 cells cultured with 10% FBS were transfected with the addition of C3a or compstatin under the influence of magnetic fields or not.
    • Biological Activity

    • Purity & Documentation

    • Customer Review

    Description

    Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4].

    In Vitro

    Compstatin exhibits an in vitro half-life in human blood of about2 hr[2].
    In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures[1].
    Compstatin is stable in baboon plasma for more than 24 h[1].
    Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Juvenile baboons (P. Anubis) weighing 10.5-28.8 kg[1].
    Dosage: 50, 25 mg/kg 60 min after heparin and 2 min before protamine.
    Administration: A bolus injection.
    Result: Completely inhibited complement activation induced by heparin–protamine complexes.
    Molecular Weight

    1550.77

    Formula

    C66H99N23O17S2

    CAS No.
    Sequence

    Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12)

    Sequence Shortening

    ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12)

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -80°C 2 years
    -20°C 1 year
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (64.48 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6448 mL 3.2242 mL 6.4484 mL
    5 mM 0.1290 mL 0.6448 mL 1.2897 mL
    10 mM 0.0645 mL 0.3224 mL 0.6448 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Purity & Documentation
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Compstatin
    Cat. No.:
    HY-P1036
    Quantity:
    MCE Japan Authorized Agent: