1. Immunology/Inflammation
  2. Complement System
  3. Compstatin TFA

Compstatin TFA 

Cat. No.: HY-P1036A Purity: 98.41%
Handling Instructions

Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Compstatin TFA Chemical Structure

Compstatin TFA Chemical Structure

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1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
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50 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Compstatin TFA:

Top Publications Citing Use of Products

Publications Citing Use of MCE Compstatin TFA

    Compstatin TFA purchased from MCE. Usage Cited in: J Mater Chem B. 2019, 7, 4207-4216.

    The transfection characterized by inverted fluorescence microscope. GFP-3T3 cells and GFP-MCF-7 cells cultured with 10% FBS were transfected with the addition of C3a or compstatin under the influence of magnetic fields or not.
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    Description

    Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3].

    In Vitro

    Compstatin exhibits an in vitro half-life in human blood of about 2 hr[2].
    In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures[1].
    Compstatin is stable in baboon plasma for more than 24 h[1].
    Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Juvenile baboons (P. Anubis) weighing 10.5-28.8 kg[1].
    Dosage: 50, 25 mg/kg 60 min after heparin and 2 min before protamine.
    Administration: A bolus injection.
    Result: Completely inhibited complement activation induced by heparin–protamine complexes.
    Molecular Weight

    1664.79

    Formula

    C₆₈H₁₀₀F₃N₂₃O₁₉S₂

    Sequence Shortening

    ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12)

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Protect from light, stored under nitrogen

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 110 mg/mL (66.07 mM; Need ultrasonic)

    H2O : 5.22 mg/mL (3.14 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6007 mL 3.0034 mL 6.0068 mL
    5 mM 0.1201 mL 0.6007 mL 1.2014 mL
    10 mM 0.0601 mL 0.3003 mL 0.6007 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.75 mg/mL (1.65 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.75 mg/mL (1.65 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.75 mg/mL (1.65 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    CompstatinComplement SystemInhibitorinhibitorinhibit

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    Compstatin TFA
    Cat. No.:
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