Serpin A6
Serpin A6 is better known as corticosteroid-binding globulin (CBG, transcortin), an unusual non-inhibitory member of the serpin superfamily. Synthesized chiefly by the liver and present in plasma at micromolar concentration, CBG carries the high-affinity binding sites for cortisol and progesterone and thus governs the distribution, half-life, and bioavailability of glucocorticoids in blood. Rather than trapping proteases, it releases hormone at sites of inflammation where neutrophil elastase cleaves its reactive center loop, lowering steroid affinity and delivering cortisol precisely where needed. Genetic CBG deficiency causes chronic fatigue and hypotension phenotypes. Recombinant Serpin A6 is used in steroid transport, binding, and regulated-release studies.
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Serpin A6 Protéines Recombinantes (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
