Serpin A11

Serpin A11 (SERPINA11) is one of the least-characterized members of the SERPINA cluster on human chromosome 14, lying within the tandem array that includes SERPINA1 and the SERPINA3 paralogs. Like its cluster neighbors, it encodes a secreted glycoprotein with the canonical serpin fold of three beta-sheet cores and an exposed reactive center loop, and transcript databases indicate expression chiefly in liver and at lower levels in other tissues, consistent with a plasma protease-inhibitor role. Because its physiological target proteases remain incompletely defined, recombinant Serpin A11 is used mainly to profile substrate specificity, generate isoform-specific antibodies, and complete coverage of the SERPINA locus for cluster research.