Kallistatin
Kallistatin (SERPINA4) is a circulating serpin distinguished by its specific inhibition of tissue kallikrein, the enzyme that releases the vasodilator peptide bradykinin from kininogen. By blocking tissue kallikrein, kallistatin modulates blood pressure, vascular permeability, and inflammation. It also exerts kallikrein-independent biological effects, including anti-angiogenic activity through binding heparin and VEGF, antioxidant actions, and protection against cardiac and renal injury in animal models. Unlike the antitrypsin branch of the family, its reactive center loop is tailored to kallikrein-type substrates. Recombinant kallistatin is used in kallikrein-kinin pathway assays, hypertension and fibrosis research, and preclinical studies of its gene or protein therapeutics.
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Kallistatin Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
