PAI-1
PAI-1 (plasminogen activator inhibitor-1, Serpin E1) is the principal physiological inhibitor of tissue-type and urokinase-type plasminogen activators, thereby gating plasmin generation, fibrinolysis and extracellular matrix remodeling. Secreted by endothelial cells, hepatocytes, adipocytes and activated platelets, it circulates both free and stabilized by vitronectin, and is released from platelet alpha-granules at thrombus sites. Expression is induced by TGF-beta, hypoxia and inflammatory cytokines. Elevated plasma PAI-1 accompanies metabolic syndrome, obesity, fibrosis and cardiovascular disease, while complete deficiency causes a mild bleeding tendency. Because active PAI-1 rapidly converts to a latent form, recombinant variants are engineered for stability in drug discovery targeting thrombosis, fibrosis and tumor invasion.
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PAI-1 Recombinant Proteins (4)
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Inhibitors & Agonists (82)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
