Emvistegrast axial isomer (Synonyms: GS-1427 axial isomer)

Cat. No.: HY-177080B Purity: 97.0%: Data Sheet
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Emvistegrast (GS-1427) axial isomer is an axial isomer of Emvistegrast (HY-177080). Emvistegrast axial isomer is an integrin α4β7 inhibtor.

For research use only. We do not sell to patients.

Emvistegrast axial isomer Chemical Structure

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Other Forms of Emvistegrast axial isomer:

Emvistegrast In-stock
(S,R)-Emvistegrast Get quote

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
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Description

Emvistegrast (GS-1427) axial isomer is an axial isomer of Emvistegrast (HY-177080). Emvistegrast axial isomer is an integrin α4β7 inhibtor^[1].

IC₅₀ & Target^[1]

α4β7

In Vitro

Emvistegrast axial isomer (Compound 487) is a prodrug, and its active ingredient (Compound 408) inhibits integrin α4β7 with an IC₅₀ of 0.049 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

708.66

Formula

C₃₅H₃₂F₄N₆O₆

Appearance

Solid

Color

Light yellow to yellow

SMILES

CCOC([C@H](CC1=CC=C(N2C(N(C3=C(C2=O)C=CN=C3)C)=O)C4=C1C=CC=N4)NC(C5=C(C=C(C=C5F)N6[C@H](COCC6)C(F)(F)F)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 97.0%

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Data Sheet (274 KB) SDS (252 KB)

COA (259 KB) HNMR (244 KB) LCMS (116 KB)

Handling Instructions (2659 KB)

References

[1]. Peter A. Blomgren, et al. Quinoline derivatives as alpha4beta7 integrin inhibitors. WO2020092375A1.

Emvistegrast axial isomer Related Classifications

Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emvistegrast axial isomerGS-1427 axial isomerDrug IsomerIntegrinaxial isomer,EmvistegrastInhibitorinhibitorinhibit

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